Deadliest serial killer in American history dies at 80, with police still searching for his victims Updated: December 30, 2020 Published December 30, 2020 In this March 4, 2013, file photo, Samuel Little appears at Superior Court in Los Angeles. Little, pronounced by the FBI the most prolific serial killer in U.S. history, has confessed to more than 90 slayings committed across the country between 1970 and 2005. (AP Photo/Damian Dovarganes, File) Share on Facebook Print article Samuel Little, the deadliest serial killer in American history, died Wednesday at the age of 80, with police around the country still searching for his victims. Little, who confessed late in life to killing 93 people across 19 states, evaded justice for more than four decades, preying on women at the margins of society. He targeted sex workers, drug users and poor, mostly Black women whose murders authorities repeatedly failed to solve or struggled to prosecute.