Nashville Tennessean The last few years have brought about a lot of changes to marijuana legislation in the United States. Here's an overview of current marijuana laws in the South. Mississippi The current fight in the Mississippi legislature involves medical marijuana. The Mississippi Supreme Court heard arguments in April in a lawsuit that's trying to block a voter-approved medical marijuana program by disputing how the issue got onto the ballot. Voters in November 2020 approved Initiative 65, which requires the state Health Department to establish a medical marijuana program by the middle of this year. The department is working to create a program, even as the legal fight continues.