that's the nature of what this awful virus has been which, as it turns out, has mutations and variants. obviously nobody can anticipate the specific next variant to come, what the protein will look like, et cetera, but in a more general sense did you not see variants coming? >> we did, jake. we definitely saw variants coming. i think we referred to what was not anticipated was the extent of the mutations and the amino acid substitutions in omicron which is really unprecedented. it kind of came out of nowhere, where you have a virus 50 mutations and 10 or 12 in the receptor binding domain. to me it's really quite unprecedented so that's something you would not have anticipated, but we certainly were anticipating that there were going to be variants. when you have so many virus, so much replication going on in the