UCI-led team to address health impacts of adverse childhood experiences using precision medicine A collaborative team centered in the University of California, Irvine (UCI) and including Children's Hospital Orange County (CHOC) and Chapman University (CU) has been awarded a three-year grant totaling in excess of $2.3 million, to address the health impacts of adverse childhood experiences (ACEs) using precision medicine. Announced by the California Governor's Office of Planning & Research, in partnership with the Office of the California Surgeon General, the award is part of the California Initiative to Advance Precision Medicine (CIAPM). The research project will begin May 2021. Led by Tallie Z. Baram, MD, PhD, Bren Distinguished Professor and director of the Conte Center at UCI, the UCI, CHOC and CU team has established two goals. The first is to identify the degree to which unpredictability of early life experiences interacts with established ACEs to influence children's neurodevelopment. The second is to employ a novel epigenetic approach, with a goal of discovering, for each child, a marker that can predict their level of resilience, so targeted interventions can be delivered to children who need them most.