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Proteomics analysis identifies potential drug targets for aggressive human cancers


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Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets. They report in the journal
Oncogene, the identification of proteomic signatures that are associated with clinical measures of aggressive disease for each of the seven cancer types studied. Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets.
There are two notable aspects of this study. One is that we explored the proteomic landscape of cancer looking for proteins that were expressed in association with aggressive forms of cancer, said co-corresponding author Dr. Chad Creighton, professor of medicine and co-director of Cancer Bio ....

United States , Baylor College Of Medicine , Darshans Chandrashekar , Yiqun Zhang , Diana Monsivais , Sooryanarayana Varambally , Yasmin Vasquez , Ramyap Masand , Fengju Chen , Johnc Faver , Michaele Scheurer , Martinm Matzuk , Burroughs Wellcome Fund , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Clinical Proteomic Tumor Analysis Consortium , Researchers At Baylor College Of Medicine , University Of Alabama At Birmingham , Cancer Prevention Research Institute Of Texas , Children Brain Tumor Tissue Consortium , Danl Duncan Comprehensive Cancer Center , Cancer Genome Atlas Consortium , Baylor College , Chad Creighton , Cancer Bioinformatics , Texas Children ,

Dialectic Therapeutics Receives FDA Clearance of IND Application for Lead Antiapoptotic Protein Targeted Degradation (APTaD) Candidate DT2216


Dialectic Therapeutics Receives FDA Clearance of IND Application for Lead Antiapoptotic Protein Targeted Degradation (APTaD) Candidate DT2216
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DALLAS, March 3, 2021 /PRNewswire/  Dialectic Therapeutics, Inc. (Dialectic
®), a Texas-based biotechnology company focused on creating innovative new technologies to treat cancer, today announced that the U.S. Food and Drug Administration (FDA) has concluded that Dialectic may proceed with its clinical investigation for its lead product candidate, DT2216, a unique compound built using its proprietary and novel
Antiapoptotic
Targeted
Degradation (APTaD™) technology. In pre-clinical studies supported through a Seed Award from the Cancer Prevention & Research Institute of Texas (CPRIT), DT2216 selectively induces cancer cells to degrade B-cell lymphoma extra-large, or BCL-XL, stimulating the cells to commit suicide or become more susceptible to chemotherapy. ....

United States , Johnd Harkey Jr , Robert Hromas , David Genecov , Josh Sills , Seed Award For Product Development Research , University Of Florida Health , Dialectic Therapeutics Inc , Ut Health San Antonio , Drug Administration , Cancer Prevention Research Institute Of Texas , Dean Of The Long School Medicine , Dialectic Therapeutics , Seed Award , Cancer Prevention , Research Institute , Chief Executive , San Antonio , Long School , Daohong Zhou , Florida Health Cancer Center , Guangrong Zheng , Florida College , Product Development Research , ஒன்றுபட்டது மாநிலங்களில் , ஜோஷ் ஸில்ஸ் ,

North Texas Inno - Roundup: the top tech and startup funding rounds, M&As and investment activity for DFW in February

North Texas Inno - Roundup: the top tech and startup funding rounds, M&As and investment activity for DFW in February
bizjournals.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from bizjournals.com Daily Mail and Mail on Sunday newspapers.

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