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Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells.
Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis.
Structure of SARS-CoV-2 cytoplasmic tail uncovered The current coronavirus disease 2019 (COVID-19) pandemic has claimed over 1.9 million lives so far, and scientists have been racing to develop vaccines that will curtail its spread. Most of these target the spike (S) protein of the virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike is anchored to the host cell membrane, as it mediates viral binding to the host cell receptor. This is the angiotensin-converting enzyme 2 (ACE2). The virus's cytosolic tail also interacts with the host cell to promote its entry into...
Researchers pinpoint spike protein regions as targets for passive and active COVID-19 vaccines Researchers at Stanford University School of Medicine have identified regions of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have relatively few mutations and might therefore serve as important targets for prophylactic agents against coronavirus disease 2019 (COVID-19). Drugs that target these “less variable” regions are more likely to be effective against future variants of SARS-CoV-2 because they remain unchanged or “conserved” as the virus mutates and evolv...
SARS-CoV-2-induced innate immune responses may vary with disease severity, finds study A team of scientists from Germany and China recently conducted a large meta-analysis using transcriptome data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to evaluate the routes of viral entry and the characteristics of innate immune responses induced by SARS-CoV-2 infection. The study reveals that SARS-CoV-2 may enter human cells via multiple routes and that angiotensin-converting enzyme 2 (ACE-2) is not the only receptor to support viral entry. Moreover, the study finds that the innate ...