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Although urate-lowering drugs form the cornerstone of gout therapy, there are only three oral medications currently available in the United States, and all have significant limitations.
Top-line results show semaglutide for weight loss (Wegovy) cut cardiovascular events in the 17,000-person SELECT CV outcomes trial, which should reframe the health benefit of this weight loss drug.
A daily prednisolone dose of less than 5 mg was not associated with increased cardiovascular risk, whereas a dose of 5 mg or more doubled the risk for major adverse cardiovascular events.
An extension study found no cases of occlusive retinal vasculitis after 23,000 injections of pegcetacoplan, but a panel received more reports of the complication and dealt with conflicts of interest.
"Are people going to think I'm crazy for doing this?"