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CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response
The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The S1 subunit has the receptor-binding domain (RBD) and the N-terminal domain (NTD). The RBD binds to the host angiotensin-converting enzyme 2 (ACE2) to infect host cells.
Neutralizing antibodies are produced against both the RBD and NTD by infected and vaccinated individuals. Some RBD-specific monoclonal antibodies are currently under clinical trials or approved for use to treat COVID-19 patients. ....

United States , Lakshmi Supriya , United States Centers For Disease Control , Phd Apr , United States Centers , Disease Control , Immune Response , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , லட்சுமி சுப்ரியா , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் க்கு நோய் கட்டுப்பாடு , ஃப்ட் ஏப்ரல் , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் , நோய் கட்டுப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants
A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Their results are currently available on the
bioRxiv preprint server.
SARS-CoV-2, the causative agent of the ongoing coronavirus disease (COVID-19), uses its spike glycoprotein to interact with angiotensin-converting enzyme 2 (ACE2) in order to fuse cell membrane and viral envelope. The key determinant of host tropism is the S1 subunit of the spike glycoprotein, composed of the receptor-binding domain (RBD) and N-terminal domain (NTD). ....

United States , South Africa , United Kingdom , South African , Kamyab Javanmardi , University Of Texas At Austin , Golden Gate , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Cell Membrane , Corona Virus , Immune Response , Polyclonal Antibody , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் இல் ஆஸ்டின் , தங்கம் வாயில் , பிணைப்பு இன உறவு , செல் சவ்வு , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச ,

Antibodies produced from infection with SARS-CoV-2 501Y.V2 protect against other variants

Antibodies produced from infection with SARS-CoV-2 501Y.V2 protect against other variants
As the coronavirus disease 2019 (COVID-19) pandemic continues to claim thousands of lives daily around the world, the pathogen responsible for it, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to undergo mutational changes. A recent paper in the journal
Nature shows that while earlier lineages do not elicit antibodies capable of efficiently neutralizing the newly emerged South African variant, SARS-CoV-2 501Y.V2 (B.1.351), the converse does occur.
The SARS-CoV-2 501Y.V2 variant
The constant occurrence of mutations in the various regions of the viral genome has led to the emergence of a multitude of variants, some of which have become global variants of concern (VOCs). ....

South Africa , South African , Oxford Astrazeneca , Liji Thomas , Alexander Limbach , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Convalescent Plasma , Corona Virus , Coronavirus Disease Covid 19 , Genomic Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , அலெக்சாண்டர் லிம்பாக் , சுறுசுறுப்பான பிளாஸ்மா , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study estimates impact of amino acid changes on SARS-CoV-2 infection

Study estimates impact of amino acid changes on SARS-CoV-2 infection
New research led by Costas D. Maranas from The Pennsylvania State University predicts amino acid changes to the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein would negatively impact binding affinity and subsequent infection into human cells.
Their results were derived from a novel two-step procedure called neural network molecular mechanics/Poisson-Boltzmann surface area (NN MM-GBSA) that calculated binding energy from receptor-binding domain variants to human angiotensin-converting enzyme 2 (ACE2) receptors. The second step would construct a neural network from the findings to predict binding affinity. The team achieved an 82.2% accuracy rate for categorizing amino acid substitutions as helpful or unhelpful in a variant s binding affinity. ....

South Africa , South African , Costasd Maranas , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Pennsylvania State University , Amino Acid , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பென்சில்வேனியா நிலை பல்கலைக்கழகம் , அமினோ அமிலம் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Novel protein construct prevents lethal COVID-19 in mice

Novel protein construct prevents lethal COVID-19 in mice
Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process.
The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and Northwestern University in Evanston – suspected that a soluble, truncated version of this membrane-bound receptor – called angiotensin-converting enzyme 2 (ACE2) – would serve as a decoy for SARS-CoV-2 spike binding and potentially neutralize infection. ....

United States , University Of Chicago , Daniel Batlle , Sally Robertson , Feinberg School Of Medicine , Northwestern University In Evanston , Feinberg School , Northwestern University , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , In Vivo , Mouse Model , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , சாலி ராபர்ட்சன் , ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு பல்கலைக்கழகம் இல் எவன்ஸ்டன் , ஃபைன்பெர்க் பள்ளி , வடமேற்கு பல்கலைக்கழகம் , பிணைப்பு இன உறவு ,