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Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?


Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?
Common immunization routes for coronavirus disease 2019 (COVID-19) vaccine candidates range from intramuscular, nasal and oral to intradermal.
Now, scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.
The study, published on the pre-print
bioRxiv server, shows another potential effective route to administer vaccines against SARS-CoV-2, the virus that causes COVID-19. Finding more ways to introduce vaccines can help combat the pandemic. ....

Angela Betsaidab Laguipo , University Of Salzburg , Angela Betsaida , Pantec Biosolutions , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , பல்கலைக்கழகம் ஆஃப் சால்ஸ்பர்க் , சர்வதேச பரவல் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines


O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines
Sites of O-glycosylation on the spike protein were near N-glycosites, suggesting O-glycans complement N-glycans effect in immune shielding.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, has some characteristics that were not seen before in human coronaviruses, such as mutation on the receptor-binding domain (RBD) for high affinity to the human angiotensin-converting enzyme 2 (ACE2) and presence of a furin cleavage site between the two subunits of the spike protein.
Several vaccines have now been approved for use, and many more are under clinical trials. Some vaccines are subunit formulations that use recombinant viral proteins for immunization. ....

Lakshmi Supriya , Orbitrap Lumos , Phd Feb , Fusion Lumos , Orbitrap Fusion Lumos , Sars Cov 2 , Spike Protein , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune System , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , லட்சுமி சுப்ரியா , ஃப்ட் ஃபெப் , இணைவு லுமோஸ் , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , எதிர் மின்னணு , நோய் எதிர்ப்பு சக்தி அமைப்பு , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,