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Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells
The clinical phenotype of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences.
To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information.
The study, published as a preprint on the
bioRxiv server, uses a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable. ....

Liji Thomas , Image Credit , Sars Cov 2 , Stem Cells , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Genetic Information , Induced Pluripotent Stem Cells , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , படம் கடன் , தண்டு செல்கள் , செல் சவ்வு , கொரோனா வைரஸ் , ஜெநெடிக் தகவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts. ....

Priyom Bose , Image Credit , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Coronavirus Disease Covid 19 , In Vivo , பிரீயோம் போஸ் , படம் கடன் , இல் விவோ , சர்வதேச பரவல் ,

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity
An allosteric center or site is one where a molecule other than the substrate to the protein can bind, altering the conformation of the protein. A paper recently uploaded to the preprint server
bioRxiv by researchers at Chapman University in California (Feb 22nd, 2021) utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants for affinity with the angiotensin-converting enzyme 2 (ACE2) receptor and monoclonal antibodies REG10987 and REG10933. The analysis allowed the group to identify allosteric centers that mediate long-range communication in the protein. The group suggests that it is these centers that allow the spike protein of SARS-CoV-2 to act in such a versatile manner, modulating the response to antibodies while conserving ACE2 affinity. ....

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Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. To date, SARS-CoV-2 has infected over 112 million people and has been responsible for over 2.48 million deaths.
While vaccines against SARS-CoV-2 are being administered globally, treatment options for those infected are still limited. A team of researchers examined PT150, which is an allosteric modulator of androgen and glucocorticoid receptors, to assess whether it had any antiviral activity or immunomodulatory activity to decrease the hyperinflammatory response of SARS-CoV-2 infection.
The researchers demonstrated PT150 as an effective inhibitor of SARS-CoV-2 infection in the Syrian golden hamster model. They found that oral PT150 given once daily for seven days prevented replication of SARS-CoV-2 in the lungs, decreased infiltration of macrophages, improved lu ....

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Cannabinoid receptor agonist shows potential protective effect on SARS-CoV-2-infected human heart cells

Cannabinoid receptor agonist shows potential protective effect on SARS-CoV-2-infected human heart cells
As scientists continue to search for effective antidotes to direct and indirect damage caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new preprint research paper posted to the
bioRxiv server demonstrates the potential of cannabinoid receptor agonists to alleviate myocardial damage in this condition even in the absence of any inhibitory effect on viral infection as such.
The features of SARS-CoV-2 infection
The SARS-CoV-2 virus appears to be a primarily respiratory virus, but it also brings about many other effects such as neurological signs and symptoms, gut symptoms, and cardiovascular features. ....

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