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The role and ancestry of the SARS-CoV-2 spike protein glycan shield

The role and ancestry of the SARS-CoV-2 spike protein glycan shield
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is a class I fusion glycoprotein responsible for interacting with the angiotensin-converting enzyme 2 (ACE2) receptor on the surface of human cells, enabling cell entry. It is the primary target of both natural and vaccine-acquired neutralizing antibodies.
The spike protein is coated in a thick glycan shield that plays a role in target site recognition, towards both the ACE2 receptor and neutralizing antibodies, and in conformational stability, modulating the state of the spike protein between closed and open forms and granting stability to the open prefusion form, which affords enhanced affinity towards the ACE2 receptor by presenting the receptor-binding domain. ....

Michael Greenwood , Panela Structure , Sars Cov 2 , Spike Protein , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , மைக்கேல் கிரீன்வுட் , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Previously approved drugs starting points for COVID-19 therapeutics

Previously approved drugs starting points for COVID-19 therapeutics
Researchers in the United States have identified several clinically approved compounds that could be repurposed for the treatment and prevention of coronavirus disease 2019 (COVID-19).
By screening a commercial library of drugs that have already been approved by international regulatory agencies, the team identified more than 50 compounds that demonstrated some efficacy in blocking the initial stage of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of COVID-19.
The compounds were able to disrupt the binding of a surface viral protein called Spike to its host cell receptor angiotensin-converting enzyme 2 (ACE2). ....

United States , Stephen Smith , Sally Robertson , Seattle Children Research Institute , Louis University School Of Medicine , Seattle Children , Research Institute , Louis University School , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Drug Discovery , In Vitro , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , மிச Ou ரி , ஸ்டீபன் ஸ்மித் , சாலி ராபர்ட்சன் , சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் , லூயிஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , சீட்டில் குழந்தைகள் , ஆராய்ச்சி நிறுவனம் ,

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells
A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the
Background
SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped RNA virus belonging to the Coronaviridae family. The virus primarily attacks human airway epithelial cells to initiate infection. Mechanistically, the receptor-binding domain (RBD) of the S1 subunit of the viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), which is ubiquitously expressed at the apical surface of host airway epithelial ce ....

United Kingdom , Juan Gaertner Shutterstock , Sanchari Sinha Dutta , Juan Gaertner , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Electron Microscopy , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , ஜுவான் கேர்ட்னெற் , செல் சவ்வு , கொரோனா வைரஸ் , எதிர் மின்னணு , எதிர் மின்னணு நுண்ணோக்கி , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response
The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The S1 subunit has the receptor-binding domain (RBD) and the N-terminal domain (NTD). The RBD binds to the host angiotensin-converting enzyme 2 (ACE2) to infect host cells.
Neutralizing antibodies are produced against both the RBD and NTD by infected and vaccinated individuals. Some RBD-specific monoclonal antibodies are currently under clinical trials or approved for use to treat COVID-19 patients. ....

United States , Lakshmi Supriya , United States Centers For Disease Control , Phd Apr , United States Centers , Disease Control , Immune Response , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , லட்சுமி சுப்ரியா , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் க்கு நோய் கட்டுப்பாடு , ஃப்ட் ஏப்ரல் , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் , நோய் கட்டுப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks
In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the
bioRxiv preprint server.
Vaccines currently in use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of COVID-19, focus on the viral spike glycoprotein that mediates cell entry by targeting angiotensin receptor 2 (ACE2) as the main receptor and heparin as the co-receptor. ....

United States , Maggie Gu , Revacc Scientific , Image Credit , Sigma Adjuvant System , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , மாகி கு , படம் கடன் , நானோ துகள்கள் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,