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In the study published in the journal Integrative Physiology, the researchers found that a high intake of polyphenols may have a protective effect on patients with COVID-19 and prevent disease progression. ....
O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines Sites of O-glycosylation on the spike protein were near N-glycosites, suggesting O-glycans complement N-glycans effect in immune shielding. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, has some characteristics that were not seen before in human coronaviruses, such as mutation on the receptor-binding domain (RBD) for high affinity to the human angiotensin-converting enzyme 2 (ACE2) and presence of a furin cleavage site between the two subunits of the spike protein. Several vaccines have now been approved for use, and many more are under clinical trials. Some vaccines are subunit formulations that use recombinant viral proteins for immunization. ....
How do mutations benefit SARS-CoV-2? To explore this, a team of researchers from China took a closer look at the physical interactions that occur between the proteins after viral mutation. ....
A new preprint on the bioRxiv server describes the development of a live attenuated vaccine candidate to counter the growing threat of the COVID-19 pandemic. ....
In a recent study conducted at the Indian Institute of Science Education and Research, India, a team of scientists screened specific genes of SARS-CoV-2 to identify factors that may contribute to viral infectivity. ....