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Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions


Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions
While the human brain has over 400 miles of total vasculature, little is known about the tiny capillaries that make up much of this intricate labyrinth of blood vessels critical for delivering oxygenated blood and nutrients to billions of brain cells.
According to Dr. Andy Shih, a principal investigator in the Center for Developmental Biology and Regenerative Medicine at Seattle Children s Research Institute, understanding how this vast network regulates blood flow in the brain could hold the key to new treatments for neonatal and childhood neurologic conditions, such as stroke and hypoxia, and issues of aging like dementia and Alzheimer s disease. ....

David Hartmann , Andy Shih , Andree Anne Berthiaume , Emily Henderson , Regenerative Medicine At Seattle Children Research Institute , Seattle Children Research Institute , Stanford University , Developmental Biology , Regenerative Medicine , Seattle Children , Research Institute , Study Principal Investigator , Nature Neuroscience , Juliane Gust , Alzheimer 39s Disease , Blood Vessels , Clinical Imaging , Imaging Techniques , In Vivo , Opto Genetics , டேவிட் ஹார்ட்மேன் , ஆண்டி ஷிஹ் , அன்றேல் அன்னே பெர்த்தியாம் , எமிலி ஹென்டர்சன் , மீளுருவாக்கம் மருந்து இல் சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் , சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் ,

Llama-derived nanobodies show neutralizing activity against SARS-CoV-2 variants of concern in vitro


Llama-derived nanobodies show neutralizing activity against SARS-CoV-2 variants of concern in vitro
With the emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, the prospect of effective containment of viral transmission has receded. Not only are they more transmissible than the earlier strains, but they also offer partial resistance to neutralization by existing antibodies in some cases. Moreover, they can evade detection by current antigen detection kits because of mutations in the spike protein with each of the new variants.
Better tests needed
This development could cause many more false-negative diagnoses to arise, giving rise to a more devastating wave of community spread. The need for more up-to-date antibody arrays is obvious. A new preprint on the ....

South Africa , United Kingdom , South African , Liji Thomas , Immunized Llama Effectively Bind Targets , South African Strains , Coronavirus Disease Covid 19 , Sars Cov 2 , Binding Affinity , Corona Virus , In Vitro , Monoclonal Antibody , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , சர்வதேச பரவல் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , இல் விட்ரோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,