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Deciphering the impacts of small RNA interactions in individual bacterial cells

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IMAGE: The panels show SgrS (red) and ptsG mRNA (green) labeled by Single-molecule Fluoresence in situ Hybridization for the wild-type strain before and after 20?min of αMG (non-metabolizable sugar analog) induction..
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Credit: Anustup Poddar
Bacteria employ many different strategies to regulate gene expression in response to fluctuating, often stressful, conditions in their environments. One type of regulation involves non-coding RNA molecules called small RNAs (sRNAs), which are found in all domains of life. A new study led by researchers at the University of Illinois describes, for the first time, the impacts of sRNA interactions in individual bacterial cells. Their findings are reported in the journal ....

United States , University Of Illinois , Zaida Luthey Schulten , Anustup Poddar , Muhammad Azam , Nature Communications , National Institutes Of Health , Jingyei Fei University Of Chicago , National Science Foundation , Carlr Woese Institute For Genomic Biology , American Academy Of Microbiology , Taekjip Ha Johns Hopkins University , Cari Vanderpool , Genomic Biology , Johns Hopkins University , Jingyei Fei , American Academy , National Institutes , Cell Biology , Molecular Biology , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் , முஹம்மது அஸாம் , இயற்கை தகவல்தொடர்புகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய அறிவியல் அடித்தளம் ,

Are 'bacterial probiotics' a game-changer for the biofuels industry?

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IMAGE: Brazil s total ethanol production in 2019 was 34.5 billion liters with domestic demand for 34 billion liters making the country the home to the largest fleet of cars that.
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Credit: The Novo Nordisk Foundation Center for Biosustainability
In a study recently published in
Nature Communications, scientists from The Novo Nordisk Foundation Center for Biosustainability (DTU) and Yale University have investigated how bacteria that are commonly found in sugarcane ethanol fermentation affect the industrial process. By closely studying the interactions between yeast and bacteria, it is suggested that the industry could improve both its total yield and the cost of the fermentation processes by paying more attention to the diversity of the microbial communities and choosing between good and bad bacteria. ....

Anheuser Busch Inbev , Morten Sommer , Felipe Lino , Yale University , Nature Communications , Group Leader , Novo Nordisk Foundation Center , Phd Student , Biofuels Annual , Biomedical Environmental Chemical Engineering , Ecology Environment , Energy Fuel Non Petroleum , அன்ஹஐசேர் புஷ் இந்பேவ் , மார்டந் சோமர் , ஃபெலிப் லினோ , யேல் பல்கலைக்கழகம் , இயற்கை தகவல்தொடர்புகள் , குழு தலைவர் , ஃப்ட் மாணவர் , உயிரி எரிபொருள்கள் ஆண்டு , உயிரி தொழில்நுட்பவியல் , உயிர் மருத்துவ சுற்றுச்சூழல் இரசாயன பொறியியல் , சூழலியல் சூழல் , ஆற்றல் எரிபொருள் அல்லாத பெட்ரோலியம் ,

Bacteria and viruses: a network of intestinal relationships | EurekAlert! Science News

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IMAGE: Network of interactions between phages (blue) and bacteria (green) present in a human microbiota. The lines represent the assignment of a phage to its bacterial host.
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Credit: Martial Marbouty / Romain Koszul
The balance of human intestinal microbiota, consisting of hundreds of bacterial species and phages (bacteria viruses), is crucial to good health. A research team, including scientists from the CNRS and the Institut Pasteur, has characterised the phage-bacterial interaction networks of the microbiota in ten healthy individuals, with unprecedented precision. Scientists detected several hundred bacterial and phage genomes and identified the thousands of interactions that bind them by quantifying the contacts between the DNA molecules of viruses and their hosts. This method has the advantage of providing exhaustive data from limited biological samples. The results were then analysed using algorithms similar to those applied to t ....

Institut Pasteur , Biostatistics Hub , நிறுவனம் பாஸ்டர் , உயிரியக்கவியல் மையம் ,

Research pinpoints unique drug target in antibiotic resistant bacteria

Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics.
The findings offer a potential new drug target in the search for effective new antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens.
The study investigated quinolone antibiotics which are used to treat a range of bacterial infections, including TB (tuberculosis). Quinolones work by inhibiting bacterial enzymes, gyrase and topoisomerase IV, thereby preventing DNA replication and RNA synthesis essential to growth.
They are highly-successful antimicrobial agents widely used in current medicine, however bacterial resistance to them and other treatments is a serious problem. ....

Tony Maxwell , Centre Of Excellence , National Natural Science Foundation Of China , University Of Tokyo , Technology Of China , Ministry Of Science , John Innes Centre , Professor Tony Maxwell , Wellcome Trust , Microbial Science , National Natural Science Foundation , International Joint Research Project , Medical Science , Professor Maxwell , Molecular Biology , Medicine Health , Pharmaceutical Science , டோனி மேக்ஸ்வெல் , மையம் ஆஃப் சிறப்பானது , தேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனா , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , தொழில்நுட்பம் ஆஃப் சீனா , அமைச்சகம் ஆஃப் அறிவியல் , ஜான் இநெஸ் மையம் , ப்ரொஃபெஸர் டோனி மேக்ஸ்வெல் , வெல்கம் நம்பிக்கை ,

Floral probiotics reduce apple disease

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IMAGE: Researchers applying probiotic sprays to blooming apple trees at the Connecticut Agricultural Experiment Station.
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Credit: Zhouqi Cui, Regan B. Huntley, Neil P. Schultes, Blaire Steven, and Quan Zeng
While many celebrate apple blossoms as classic signs of spring, they are also welcoming entry gates for pathogens. Full of nutrients to lure pollinators and promote pollen germination, flowers also attract bacteria like
Erwinia amylavora, a pathogen that causes a damaging disease called fire blight. However, recent work by scientists at the Connecticut Agricultural Experiment Station suggests that these flowery infection sites might also be perfect targets for applying microbial fire blight biocontrol measures. ....

University Of Connecticut , United States , Zhouqi Cui , Quan Zeng , Mia Howard , Jen Lau , Blaire Steven , Neil Schultes , Regan Huntley , Zhouqi Cui Cuizhouqi , Indiana University , Department Of Plant Pathology , Department Of Plant Science , Connecticut Agricultural Experiment Station , Phytobiomes Journal , Stigma Colonizing Microbes , Apple Stigmas Alters Microbiome Structure , Fire Blight Disease , Associate Scientist , Plant Pathology , Plant Science , Landscape Architecture , Agricultural Production Economics , Food Science , Plant Sciences , Ecology Environment ,