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How antibiotic-filled poop helps 'bessbug' beetles stay healthy

Researchers at the University of California, Berkeley, have discovered that the frass of the horned passalus beetle is teeming with antibiotic and antifungal chemicals similar to the ones that humans use to ward off bacterial and fungal infections. Understanding the symbiotic relationship between bessbug beetles, actinomycetes and their antimicrobial compounds could help speed the search for new antibiotic drugs, and help doctors create better strategies for preventing the rise of antibiotic-resistant infections. ....

United States , North Carolina , Laila El Hifnawi , Eoinl Brodie , Matthew Traxler , Eoin Brodie , Cassia Pessotti , Lawrence Berkeley , Florence Pessotti , Javier Ceja Navarro , National Laboratory , University Of California , Lawrence Berkeley National Laboratory , Us Department Of Energy , Rita De Cassia Pessotti , Lawrence Berkeley National , Jewel Reaso , Ecology Environment , Infectious Emerging Diseases , ஒன்றுபட்டது மாநிலங்களில் , வடக்கு கரோலினா , மேத்யூ டிராக்ஸ்லர் , எயாய்ந் பிராடி , லாரன்ஸ் பெர்க்லி , தேசிய ஆய்வகம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா ,

Research uncovers how 'non-professional' cells can trigger immune response

Researchers are finding new details on the complex dynamics involved in how organisms sense an infection from pathogens. The researchers found that worms can sense changes in their metabolism in order to unleash protective defenses, even if they don t directly sense an incursion from pathogens. ....

San Diego , United States , University Of California San Diego , Latisha Franklin , Bryan Underwood , Wendy Hanna Rose , Eillen Tecle , Emily Troemel , Pennsylvania State University , Division Of Biological Sciences , California San Diego , Diego Assistant Project Scientist Eillen Tecle , Professor Emily Troemel , Biological Sciences , Crystal Chhan , Cell Biology , Medicine Health , Immunology Allergies Asthma , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , லதிஷா பிராங்க்ளின் , ரியான் அஂடர்‌வுட் , பென்சில்வேனியா நிலை பல்கலைக்கழகம் , பிரிவு ஆஃப் உயிரியல் அறிவியல் , கலிஃபோர்னியா சான் டியாகோ ,

Newly discovered enzymes are not heavy metal fans

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IMAGE: Researchers from the University of Tsukuba have identified a new type of carbonic anhydrase enzyme that can convert CO2 to HCO3- without the use of a metal ion. This discovery.
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Credit: University of Tsukuba
Tsukuba, Japan - Carbonic anhydrases are essential enzymes that are present in virtually all living things; all eight classes of carbonic anhydrases that have been identified to date need a metal ion to function. But now, researchers from Japan have discovered that metal is not crucial for all carbonic anhydrases.
In a study published this month in
BMC Biology, researchers from the Faculty of Life and Environmental Sciences at the University of Tsukuba have described two members of the COG4337 protein family that are the first known examples of carbonic anhydrase enzymes that do not require a metal ion to function. ....

Yoshihisa Hirakawa , Environmental Sciences , University Of Tsukuba , Professor Yoshihisa Hirakawa , Cell Biology , Ecology Environment , Molecular Biology , Climate Change , சுற்றுச்சூழல் அறிவியல் , பல்கலைக்கழகம் ஆஃப் ட்சூகுபா ,

Stanford bioengineer aims to turn nature's virus fighters into powerful drugs

Years of development and testing remain before peptoid drugs, based on peptide-like molecules, could possibly make it to market. But encouraging results thus far suggest they have the potential to become a new category of antiviral treatments for everything from herpes and COVID-19 to the common cold. ....

Stanford School Of Engineering , Gill Diamond University Of Louisville , Annelise Barron , Stanford School , Gill Diamond , Molecular Biology , Pharmaceutical Sciences , Medicine Health , Pharmaceutical Science , ஸ்டான்போர்ட் பள்ளி ஆஃப் பொறியியல் , அந்நெலிசே பரோன் , ஸ்டான்போர்ட் பள்ளி , கில் வைரம் ,

Can antibiotics treat human diseases in addition to bacterial infections?

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IMAGE: An antibiotic (green), bound in the human-like yeast ribosome (gray), allows for synthesis of some proteins (represented in orange, purple, and blue) but not others (dark green).
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Credit: Maxim Svetlov/UIC
According to researchers at the University of Illinois Chicago, the antibiotics used to treat common bacterial infections, like pneumonia and sinusitis, may also be used to treat human diseases, like cancer. Theoretically, at least.
As outlined in a new
Nature Communications study, the UIC College of Pharmacy team has shown in laboratory experiments that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do. ....

United States , Alexander Mankin , Daniel Wilson , Norbert Polacek , Maxim Svetlov , Timm Koller , Vaishnavi Shankar , Sezen Meydan , Dorota Klepacki , Nicholas Guydosh , Nature Communications , University Of Illinois Chicago , National Institutes Of Health , University Of Hamburg , German Research Foundation , University Of Bern , College Of Pharmacy , Swiss National Science Foundation , Illinois Chicago , Alexander Neyfakh Professor , Medicinal Chemistry , National Institutes , Pharmaceutical Sciences , Pharmaceutical Combinatorial Chemistry , Medicine Health , Disease In The Developing World ,