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Lindquist investigator research on mucormycosis, the deadly 'black fungus'

Credit: The Lundquist Institute
LOS ANGELES (May 13, 2021) The Lundquist Institute today announced that one of its spinoff start-up companies, Vitalex Biosciences, founded by researcher Dr. Ashraf Ibrahim, is producing an antibody that stems the spread of mucormycosis, a deadly fungal infection with an overall mortality rate of 50% and higher. Mucormycosis is an emerging infection caused by exposure to mucor, a mold commonly found in soil, plants, manure, and decaying fruits and vegetables. It affects the sinuses, the brain and the lungs and is life-threatening in diabetic or severely immunocompromised individuals, such as cancer patients. In addition to the >50% death rates, extremely disfiguring surgery is often needed to remove necrotic tissues. ....

Vitalex Biosciences , Max Benavidez , Ashraf Ibrahim , Small Business Innovation Research , National Institute Of Allergy , Lundquist Institute , National Institute , Infectious Diseases , Medicine Health , Aids Hiv , Critical Care Emergency Medicine , Death Dying , Infectious Emerging Diseases , Public Health , Disease In The Developing World , அதிகபட்சம் பெனாவிடெஸ் , அஷ்ரஃப் இப்ராஹிம் , சிறிய வணிக கண்டுபிடிப்பு ஆராய்ச்சி , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை , லண்ட்கிஸ்ட் நிறுவனம் , தேசிய நிறுவனம் , தொற்று நோய்கள் ,

Dental procedures during pandemic are no riskier than a drink of water

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COLUMBUS, Ohio - A new study s findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist s office.
SARS-CoV-2 spreads mainly through respiratory droplets, and dental procedures are known to produce an abundance of aerosols - leading to fears that flying saliva during a cleaning or a restorative procedure could make the dentist s chair a high-transmission location.
Ohio State University researchers set out to determine whether saliva is the main source of the spray, collecting samples from personnel, equipment and other surfaces reached by aerosols during a range of dental procedures.
By analyzing the genetic makeup of the organisms detected in those samples, the researchers determined that watery solution from irrigation tools, not saliva, was the main source of any bacteria or viruses present in the spatter and spurts from patients mouths. ....

United States , Ohio State University , Purnima Kumar , Shwetha Saraswat , Emily Caldwell , Archana Meethil , Shareef Dabdoub , Prem Prashant Chaudhary , Journal Of Dental Research , Ohio State College Of Dentistry , National Institute Of Allergy , State University , Ohio State , National Institute , Medicine Health , Dentistry Periodontal Disease , Health Professionals , Infectious Emerging Diseases , Public Health , ஒன்றுபட்டது மாநிலங்களில் , ஓஹியோ நிலை பல்கலைக்கழகம் , பூர்ணிமா குமார் , எமிலி கால்டுவெல் , இதழ் ஆஃப் டெஂடல் ஆராய்ச்சி , ஓஹியோ நிலை கல்லூரி ஆஃப் பல் மருத்துவம் , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை ,

How the body builds a healthy relationship with 'good' gut bacteria

Research published in Nature reveals insights into how the body maintains balance with good gut bacteria that allows these microbes to flourish in the intestine but keeps them out of tissues and organs where they re not supposed to be. ....

Gretchen Diehl , Matthew Bettini , Nu Health , National Institutes Of Health , Kleberg Foundation , Washington University School Of Medicine , Sloan Kettering Institute , Lymphoma Society Scholar Award , Kenneth Rainin Foundation , Baylor College Of Medicine , Baylor College , Washington University School , National Institutes , Lymphoma Society Scholar , Developmental Reproductive Biology , Molecular Biology , Medicine Health , Immunology Allergies Asthma , Metabolism Metabolic Diseases , க்ரெசந் டீல் , உ ஆரோக்கியம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , கிலேபெர்க் அடித்தளம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஸ்லோன் கெட்டரிங் நிறுவனம் , லிம்போமா சமூகம் அறிஞர் விருது ,

Elegant constrictions in a cellular kill switch

Combining expertise has shed new light on how cells self-destruct during microbial infection. ....

Mo Li , Xin Gao , Maojun Yang At Tsinghua University , Tsinghua University , Baolei Yuan , Maojun Yang , Titan Krios , Cell Biology , Molecular Biology , மோ லி , க்ஷின் கொ ,

Crohn's disease patients have specific IgG antibodies to human bacterial flagellins

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IMAGE: Last year, researchers used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a proof-of-principle demonstration that a flagellin-directed immunotherapy might provide similar benefits in.
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Credit: UAB
BIRMINGHAM, Ala. - Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn s disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn s disease in a flagellin peptide-specific immunotherapy. This study provided proof-of-principle that a flagellin-directed immunotherapy might provide similar benefits in patients.
Now University of Alabama at Birmingham researchers have moved a step closer to possible clinical testing of this treatment, say Elson and co-first authors Katie Alexander, Ph.D., and Qing Zhao, M.D., Ph.D. Their study, published in the journal ....

United States , Peterj Mannon , Charleso Elson , Qing Zhao , Katie Alexander , Basili Hirschowitz , Alexanderf Rosenberg , Meagan Reif , National Institutes Of Health , Department Of Medicine Division Gastroenterology , University Of Alabama At Birmingham , Department Of Microbiology , Colitis Foundation Of America , Department Of Veterans Affairs , Department Of Medicine , Rainin Foundation , Medicine Division , Lennard Wayne Duck , Colitis Foundation , Veterans Affairs , National Institutes , Synergy Award , Endowed Chair , Medicine Health , Immunology Allergies Asthma , Internal Medicine ,