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To combat gum disease, help oral bacteria evolve


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Tsukuba, Japan Liver disease, from metabolic and bacterial causes, is a growing concern. What connects these dots? The gut, or more specifically, bacteria in the gut. Bacteria that cause inflammation in the mouth are transported through the digestive tract to the gut and liver, where they can cause liver inflammation. Lipopolysaccharides, important structural molecules in some bacteria, act as endotoxins, producing systemic effects that can manifest as non-alcoholic fatty liver disease (NAFLD). Now, a multidisciplinary team from the University of Tsukuba show that exercise could be used to improve the oral environment in people with NAFLD, potentially leading to a new treatment for the disease. ....

Junichi Shoda , Public Health , International Journal Of Environmental Research , University Of Tsukuba , Professor Junichi , Oral Microbiota , Alcoholic Fatty Liver Disease , International Journal , Environmental Research , Medicine Health , Dentistry Periodontal Disease , Diet Body Weight , Metabolism Metabolic Diseases , பொது ஆரோக்கியம் , சர்வதேச இதழ் ஆஃப் சுற்றுச்சூழல் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் ட்சூகுபா , ஆல்கஹால் கொழுப்பு கல்லீரல் நோய் , சர்வதேச இதழ் , சுற்றுச்சூழல் ஆராய்ச்சி , உயிர் வேதியியல் , மருந்து ஆரோக்கியம் , பல் மருத்துவம் பெரியடாஂடல் நோய் , உணவு உடல் எடை , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் ,

DNA methylation from bacteria & mircobiome using nanopore technology discovered


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IMAGE: Gang Fang, PhD, Associate Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
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Credit: Mount Sinai Health System
Journal Name:
Nature Methods
Title of the Article: Discovering multiple types of DNA methylation from individual bacteria and microbiome using nanopore sequencing
Corresponding Author: Gang Fang, PhD
Bottom Line:
Bacterial DNA methylation occurs at diverse sequence contexts and plays important functional roles in cellular defense and gene regulation. An increasing number of studies have reported that bacterial DNA methylation has important roles affecting clinically relevant phenotypes such as virulence, host colonization, sporulation, biofilm formation, among others. ....

Elizabeth Dowling , Why The Research Is Interesting , Public Affairs , Journal Name , Gang Fang , Research Is Interesting , Mount Sinai , Cell Biology , Molecular Biology , Medicine Health , Nanotechnology Micromachines , எலிசபெத் டௌலிஂக் , ஏன் தி ஆராய்ச்சி இருக்கிறது சுவாரஸ்யமானது , பொது வாழ்க்கைத்தொழில்கள் , இதழ் பெயர் , கும்பல் ஃப்யாஂக் , ஆராய்ச்சி இருக்கிறது சுவாரஸ்யமானது , ஏற்ற சினை , உயிரி தொழில்நுட்பவியல் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , மருந்து ஆரோக்கியம் ,

Evolved to stop bacteria, designed for stability


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Connections are crucial. Bacteria may be most dangerous when they connect - banding together to build fortress-like structures known as biofilms that afford them resistance to antibiotics. But a biomolecular scientist in Israel and a microbiologist in California have forged their own connections that could lead to new protocols for laying siege to biofilm-protected colonies. Their research was published in the
Proceedings of the National Academy of Sciences (
PNAS), USA.
This interdisciplinary collaboration began with a lecture given at the Weizmann Institute of Science in the Life Sciences Colloquium. Prof. Dianne Newman of the California Institute of Technology was the speaker, and the Institute s Prof. Sarel Fleishman, of the Biomolecular Sciences Department, decided to attend, even though the lecture had no immediately apparent bearing on his own research. Newman described an enzyme she had discovered that could interrupt the metabolism of the biofi ....

United States , California Institute Of Technology , Olga Khersonsky , Sam Switzer , Carolyn Hewitt , Chelseym Vandrisse , Anne Christopoulos , Sarel Fleishman , Rosalie Lipsh Sokolik , Dianne Newman , Sarel Jacob Fleishman , Irving Kipnes Foundation , Joycee Eisenberg Foundation , Weizmann Institute Of Science , Life Sciences Colloquium , Barry Sherman Institute For Medicinal Chemistry , Proceedings Of The National Academy Sciences , Biomolecular Sciences Department , Institute Prof , Milner Foundation , Schwartz Reisman Collaborative Science Program , Sela Center , Sam Ousher Switzer Charitable Foundation , National Academy , Weizmann Institute , Life Sciences ,