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FTY720 inhibits development of collagen-induced arthritis

Oral administration of fingolimod inhibits CD4+T lymphocyte recruitment and TNF-a-induced inflammation in a collagen-induced arthritis mouse model. Read more. ....

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Forsythoside A- potential treatment for diabetic nephropathy

Forsythoside A- potential treatment for diabetic nephropathy
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Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiati

7,8 and organ protection from ischemia/reperfusion injury.
9,10 Newly synthesized transition metal carbonyl-compounds, CO release molecules (CORMs), are effective in regulating CO release in vivo and in vitro in appropriate circumstances.
11 These CO releasing molecules can therefore be used as the new carrier to provide exogenous CO. CORM-3 [tricarbonylchloro (glycinato) ruthenium (II)] is completely soluble in water with fast release of CO when dissolved in a physiological solution.
By releasing CO, CORMs also induce an anti-inflammatory effect. Our previous study showed that CORM-2 reduced periodontal inflammation and alveolar bone resorption in rats with experimental periodontitis.
13 We also reported CORM-3 suppressed the expression of adhesion molecules in human gingival fibroblasts co-stimulated by tumor necrosis factor-α and interleukin-1 β, ....

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Biliverdin protects against cerebral ischemia - NDT

Junjie Li,
Wenya Bai, Peihua Peng, Wendong Chen, Wei Yang, Jianlin Shao
Department of Anesthesiology, First Affiliated Hospital, Kunming Medical University, Kunming City, 650032, People’s Republic of China
These authors contributed equally to this work
Correspondence: Jianlin Shao
Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Wuhua, Kunming, Yunnan, 650000, People’s Republic of China
Tel +86-871-6532488-2755
Background: We have previously demonstrated that biliverdin has neuroprotective effects that ameliorate cerebral ischemia/reperfusion (I/R) injury in rats. However, the underlying mechanism is unknown. This study aimed at elucidating on the modulatory role of miR-27a-3p on Rgs1 as a mechanism by which biliverdin affects cerebral I/R injury. ....

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[Full text] Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon

[Full text] Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon
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