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There's a surprising amount of information stored in the hardened plaque, or calculus, between teeth. And if that calculus belongs to the remains of a person who lived in ancient times, the information could reveal new insights about the past. But the tiny samples can be difficult to work with. Now, in ACS'
E-Mail IMAGE: Scientists from the University of Konstanz and the Free University of Amsterdam, in collaboration with the Bruker BioSpin development team, have succeeded for the first time in the direct spectroscopic... view more Credit: Malte Drescher Lab - University of Konstanz The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease. Despite the high interest of biomedical research in the protein, many questions concernin...
E-Mail IMAGE: Researchers have precisely mapped the binding locations of over 400 proteins on the yeast genome using ChIP-exo. The method (top) uses an antibody to 'fish out' a specific DNA-bound protein... view more Credit: Pugh Lab, Cornell and Mahony Lab, Penn State A massive effort to map the precise binding locations of over 400 different kinds of proteins on the yeast genome has produced the most thorough and high-resolution map of chromosome architecture and gene regulation to date. The study reveals two distinct gene regulatory architectures, expanding the traditional mode...
E-Mail IMAGE: When TRF1 is phosphorylated by AKT, telomeres are normal (top); in the cell lines where AKT doesn't modify TRF1, telomeres are shorter and have a lower potential to generate tumours... view more Credit: PLOS Genetics The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre (CNIO) continues to make progress in unravelling the role that telomeres -the ends of chromosomes that are responsible for cellular ageing as they shorten- play in cancer. The CNIO team was among the first to propose that shelterins, proteins that wra...
Compounds in green and black tea relax blood vessels by activating ion channel proteins A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Published in Cellular Physiology and Biochemistry, the discovery was made by the laboratory of Geoffrey Abbott, PhD, a professor in the Department of Physiology and Biophysics at the UCI...