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AI algorithm accurately detects disease-causing variants in infants with rare diseases

Fabric Genomics and Rady Children's Institute for Genomic Medicine today announced the publication of a retrospective study in Genome Medicine showing that across six leading genomic centers and hospitals, researchers were able to detect more than 90% of disease-causing variants in infants with rare diseases using the Fabric GEM AI algorithm and whole-genome and whole-exome data from previously diagnosed newborns and rare disease patients at Rady Children's Hospital - San Diego and other clinical sites. ....

United States , San Diego , Stephen Kingsmore , Mark Yandell , Martin Reese , Emily Henderson , Tartu University Hospital , Rady Children Institute For Genomic Medicine , Study Co , Translational Genomics Research Institute Tgen , University Of Utah , Hudsonalpha Institute Of Biotechnology , Christian Albrechts University Of Kiel Hospital Schleswig Holstein , Rady Children , Genome Medicine , Study Co Author , Boston Children , Christian Albrechts University , University Hospital Schleswig Holstein , Hudsonalpha Institute , Translational Genomics Research Institute , Human Genetics , Edna Benning Presidential Endowed Chair , Human Phenotype Ontology , Fabric Genomics , Artificial Intelligence ,

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Researchers review diverse computational methods for drug/inhibitor design and enzymes as potential targets for inhibitors to treat coronaviruses diseases. ....

International Journal Of Antimicrobial Agents , International Journal , Antimicrobial Agents , Molecule Transformer Drug Target Interaction , Coronavirus Disease Covid 19 , Ars Cov 2 , Deep Learning , Health Systems , Immune Response , Ibonucleic Acid , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein ,

Common oral diuretic pill may be a potential candidate for Alzheimer's treatment

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging. ....

New York , United States , San Francisco , Richardj Hodes , Emily Henderson , University Of California , Division Of Neuroscience , Icahn School Of Medicine At Mount Sinai , National Institutes Of Health , Drug Administration , National Institute On Aging , Drug Development , National Institute , National Institutes , Jean Yuan , Translational Bioinformatics , Gladstone Institutes , Icahn School , Mount Sinai , Lzheimer 39s Disease , Ene Expression , Medical Research ,

Human coronavirus replicates in bats without using the spike protein

Researchers in Singapore have conducted a study showing active replication of a human coronavirus in bats that occurred without the viral spike protein binding to host cell receptors. ....

Martin Linster , Sally Robertson , Bioinformatics Institute , Middle East Respiratory Syndrome , Coronavirus Disease Covid 19 , Spike Protein , Ngiotensin Converting Enzyme 2 , Medical School , Protein Expression , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Researchers develop artificial intelligence method to predict anti-cancer immunity

Researchers and data scientists at UT Southwestern Medical Center and MD Anderson Cancer Center have developed an artificial intelligence technique that. ....

Jun Wang , Donl Gibbons , Chantale Bernatchez , Lin Xu , Xue Xiao , Peixin Jiang , Tao Wang , Yunguan Wang , Tianshi Lu , Johnv Heymach , James Zhu , Alexandre Reuben , Langone Health , National Cancer Institute , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , Md Anderson Cancer Center , Ut Southwestern Simmons Cancer Center , Waun Ki Hong Lung Cancer Research Fund , Ut Southwestern Medical Center , University Cancer Foundation , Rexanna Foundation For Fighting Lung Cancer , National Human Genome Research Institute , Data Sciences , Research Institute Of Texas , Medical Center ,