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Could our immune system be why COVID-19 is so deadly?

Credit: Earlham Institute
Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyse an overactive immune response that leads to a life-threatening cycle, known as a cytokine storm. Analysing cytokine responses from patients infected with SARS-CoV-2 and similar common respiratory viruses has unearthed glaringly important differences in how SARS-CoV-2 affects cytokines compared to other common respiratory viruses.
The comprehensive data resource aims to help specialists identify better treatments and diagnosis of underlying causes that can cause the deadly cytokine storm.
Scientists at the Earlham Institute (EI) and the Quadram Institute study how the immune system responds to infection with SARS-CoV-2 and other similar respiratory viruses, in particular to identifying unique features in severely ill COVID-19 patients. ....

Claire Shannon Lowe , Marton Olbei , Quadram Institute , Earlham Institute , Members Of The Korcsmaros Group , University Of Birmingham , Korcsmaros Group , Phd Student Marton Olbei , Molecular Biology , Medicine Health , Immunology Allergies Asthma , Infectious Emerging Diseases , Technology Engineering Computer Science , கிளாரி ஶ்யாநந் குறைந்த , ஏர்ல்தாம் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் பர்மிங்காம் , மூலக்கூறு உயிரியல் , மருந்து ஆரோக்கியம் , நோயெதிர்ப்பு ஒவ்வாமை ஆஸ்துமா , தொற்று வளர்ந்து வருகிறது நோய்கள் , தொழில்நுட்பம் பொறியியல் கணினி அறிவியல் , உயிர் தகவலியல் ,

The enemy within: Understanding the mechanisms of r-chop resistance in b-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP the standard treatment regimen. Can one treatment then benefit all patients? In a review published in Chinese Medical Journal, researchers comprehensively summarize the molecular pathways and tumor microenvironment alterations across DLBCL that contribute to drug resistance and suggest a tailored treatment approach by screening for predictors of drug resistance. ....

Aliang Wang , Chinese Medical , Cell Biology , Medicine Health , Pharmaceutical Science , லியாங் வாங் , சீன மருத்துவ , உயிர் வேதியியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , மருந்து அறிவியல் , உயிர் தகவலியல் ,

Landmark study details sequencing of 64 full human genomes to better capture genetic diversity

Credit: NIH
Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal
Science, that details the sequencing of 64 full human genomes. This reference data includes individuals from around the world and better captures the genetic diversity of the human species. Among other applications, the work will enable population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation.
Twenty years ago this month, the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence. The Human Genome Project, as it was called, required 11 years of work and involved more than 1000 scientists from 40 countries. This reference, however, did not represent a single individual, but instead was a composite of humans that could not accurately capture the complexity of human genetic variation. ....

Akikok Bowers , Nelson Chuang , E Albert Reece , Pacific Biosciences , Pacific Bioscences , Scott Devine , Luke Tallon , International Human Genome Sequencing Consortium , Genome Resource Center , University Of Washington , University Of Maryland School Medicine , Genomic Resource Center , Institute Of Genome Science , Institute For Genome Sciences , Maryland School , Human Genome Project , Associate Professor , Genome Science , Jackson Labs , Genome Sciences , Scientific Director , Executive Vice President , Medical Affairs , Distinguished Professor , Molecular Biology , Medicine Health ,

New, more reliable testing program rolled-out to hospital staff to curb Covid transmission rates

New, more reliable testing program rolled-out to hospital staff to curb Covid transmission rates
Frontline staff at Norfolk and Norwich University Hospitals (NNUH) are among the first in the country to benefit from the rollout of more accurate saliva tests in a bid to curb Covid transmission rates.
Combined with the vaccination programme, these rapid tests should help to significantly reduce the ability of the virus to spread in healthcare settings.
In partnership with the Norfolk and Norwich Pathology Lab, the Earlham Institute (EI) and the Eastern Pathology Alliance, the Government-commissioned programme introduces a new, more reliable COVID testing programme for frontline workers. ....

Ngozi Elumogo , Richard Goodwin , Karim Gharbi , Neil Hall , Emily Henderson , Norwich Research Park , Norwich Pathology Lab , Eastern Pathology Alliance , Consultant Microbiologist Lab Medicine Clinical , Norwich University Hospitals , Waveney Health Partnership , Earlham Institute , Clinical Support Services , Norwich Research , Genomics Pipelines , Clinical Lead , Covid Testing , Pathology Incident Director , Consultant Microbiologist , Lab Medicine Clinical Director , Health Care , ரிச்சர்ட் குட்வின் , நீல் மண்டபம் , எமிலி ஹென்டர்சன் , நார்விச் ஆராய்ச்சி பூங்கா , நார்விச் நோயியல் ஆய்வகம் ,

NIH awards UC San Diego $33 million for five COVID-19 diagnostic projects

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IMAGE: A nurse tests students for COVID-19 as they arrive on the UC San Diego campus.
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Credit: Erik Jepsen/UC San Diego
University of California San Diego was awarded five Rapid Acceleration of Diagnostics (RADx) projects by the National Institutes of Health (NIH), totaling nearly $33 million over four years. The purpose of the RADx initiative is to speed innovation in the development, commercialization and implementation of technologies for COVID-19 testing.
There are several programs within the RADx initiative, including the RADx Underserved Populations (RADx-UP) program, which funds projects aimed at understanding why some communities are disproportionately affected by COVID-19 and reducing the factors associated with these disparities, and the RADx Radical (RADx-rad) program, which supports innovative approaches to addressing gaps in COVID-19 testing. ....

United States , San Diego County , San Diego , University Of California San Diego , University Of Texas , Jesse Nodora , Lucila Ohno Machado , Louise Laurent , Jane Burns , Jesse Jokerst , Wuhua Xu , Elena Mart , Diego Halicio , Samm Walton , Robert Tukey , Linda Hill , Diego Radx Rad , Eliah Aronoff Spencer , Department Of Biomedical Informatics , Herbert Wertheim School Of Public Health , Uc San Diego Jacobs School Of Engineering , Cancer Research , Health Quality Partners Of Southern California , Uc San Diego Health , Data Science Institute , Translational Research Institute ,