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"Good bacteria" in breast milk changes over time

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“Good bacteria” in breast milk changes over time
Scientists discover complex and dynamic bacterial ecosystem in human breast milk using genomic technology pioneered for the International Space Station
The cocktail of beneficial bacteria passed from mother to infant through breast milk changes significantly over time and could act like a daily booster shot for infant immunity and metabolism. The research, conducted by scientists from Montreal and Guatemala and published in Frontiers in Microbiology, has important implications for infant development and health.
Researchers discovered a range of microbiome species never before identified in human milk. Until now, relatively little was known about the role microbiome bacteria play in breast milk. These bacteria are thought to protect the infant gastrointestinal tract and improve aspects of long-term health, such as allergy prevention. ....

United States , Emmanuel Gonzalez , Agellon Luis , Kristine Koski , Scott Marilyn , Gonzalez Emmanuel , Brereton Nicholas , Lopez Leyva Lilian , Koski Kristine , Solomons Noel , Li Chen , World Health Organization , School Of Human Nutrition At Mcgill , Mcgill University , Mcgill University Is Canada , University Of Montreal , International Space , Western Highlands , North America , Associate Professor , Human Nutrition , Changes Occur , Human Breast Milk Microbiome Between Early , Established Lactation , Breastfeeding Guatemalan , International Students ,

'Good bacteria' in breast milk changes over time

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IMAGE: Figure 1: Flower diagram representing the major bacterial groups (phyla) within the milk microbiome of Mam-Mayan Guatemalan mothers
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Credit: Emmanuel Gonzalez et al.
The cocktail of beneficial bacteria passed from mother to infant through breast milk changes significantly over time and could act like a daily booster shot for infant immunity and metabolism. The research, conducted by scientists from Montreal and Guatemala and published in
Frontiers in Microbiology, has important implications for infant development and health.
Researchers discovered a range of microbiome species never before identified in human milk. Until now, relatively little was known about the role microbiome bacteria play in breast milk. These bacteria are thought to protect the infant gastrointestinal tract and improve aspects of long-term health, such as allergy prevention. ....

United States , Emmanuel Gonzalez , Agellon Luis , Kristine Koski , Scott Marilyn , Gonzalez Emmanuel , Brereton Nicholas , Lopez Leyva Lilian , Koski Kristine , Solomons Noel , Li Chen , World Health Organization , School Of Human Nutrition At Mcgill , Mcgill University , University Of Montreal , International Space , Western Highlands , North America , Associate Professor , Human Nutrition , Changes Occur , Human Breast Milk Microbiome Between Early , Established Lactation , Breastfeeding Guatemalan , Nutrition Nutrients , Medicine Health ,

New technique reveals switches in RNA

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IMAGE: This is Dr. Danny Incarnato, a molecular geneticist at the University of Groningen, the Netherlands. In collaboration with colleagues from the University of Torino (Italy), his team developed a method.
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Credit: University of Groningen
Scientists at the University of Groningen (The Netherlands), in collaboration with colleagues from the University of Torino (Italy), have developed a method to visualize and quantify alternative structures of RNA molecules. These alternative RNA shapes can have important functional relevance in viruses and bacteria. The researchers used an algorithm to rapidly analyse large quantities of chemically modified RNA molecules and calculate how many differently folded conformations were present. This technique was used to identify a conserved structural switch in the RNA of the SARS-CoV-2 virus. The results of this analysis were published in the journal ....

Edoardo Morandi , Ilaria Manfredonia , Danny Incarnato , Lisam Simon , Francesca Anselmi , University Of Torino , University Of Groningen , Nature Methods , Salvatore Oliviero , Biomechanics Biophysics , Infectious Emerging Diseases , Pharmaceutical Science , எடொஅறுதோ மொராண்டி , பல்கலைக்கழகம் ஆஃப் டொரினோ , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , இயற்கை முறைகள் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , உயிர் வேதியியல் , தொற்று வளர்ந்து வருகிறது நோய்கள் , மருந்து அறிவியல் , உயிர் தகவலியல் ,

Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas

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Credit: Cancer Biology & Medicine
Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass. Hepatocellular carcinoma (HCC), being highly malignant and invasive with a high recurrence rate and drug resistant phenotype, is one of the most dreadful cancers. Understanding the underlying molecular mechanisms is crucial to design therapeutic interventions and to predict patient prognosis.
Cancer cells use metabolic, immunogenic, or growth-related strategies, which can be controlled by a number of alterations in the cell process. Of these, post-transcriptional RNA modification has recently sparked interest among cancer biologists. N6-methyladenosine (m6A) methylation, a type of RNA modification, remains the most abundant epigenetic (non-DNA related) modification in eukaryotic cells. Abnormal activity of proteins that handle m6A re ....

Wei Qin , Lun Xiu Qin , Ryan Fu , Qiongzhu Dong , Lunxiu Qin , Jing Xu , Xiaotian Shen , Institutes Of Biomedical Sciences , Fudan University , International Cancer Genome Consortium , Shanghai Medical College , Huashan Hospital Cancer Metastasis Institute , Cancer Biology , Cancer Genome Atlas , Shun Wang , General Surgery , Huashan Hospital , Cancer Metastasis Institute , Biomedical Sciences , Cell Biology , Developmental Reproductive Biology , Medicine Health , வெய் குயின் , லூந் க்ஷிு குயின் , யான் ஃபூ , ஜிங் ஐயூ ,

Are antibody cocktails the key to COVID-19 treatment?

Are antibody cocktails the key to COVID-19 treatment?
Thought LeadersDr. Natalia FreundAssistant Professor, Sackler School of MedicineTel Aviv University
In this interview, News-Medical speaks to Dr. Natalia Freund about her latest research into COVID-19, and how most people are capable of producing neutralizing antibodies against the virus.
What provoked your research into the ongoing COVID-19 pandemic?
When the pandemic hit Israel, every aspect of our lives has changed, and therefore like many other laboratories we had to put on hold some ongoing projects and focus on the new virus.
In fact, we have been developing tools and platforms for antibody discovery and isolation for a very long time, while focusing on other infectious diseases such as HIV-1 and Tuberculosis, and we were as prepared as one can be to apply our tools to the new COVID-19 problem. ....

New York , United States , Rockefeller University , Michel Nussenzweig , Cristian Moga Shutterstock , Natalia Freund , Emily Henderson , Kateryna Kon Shutterstock , Ichilov Center , Kaplan Centers , Life Sciences Faculty , Cell Research , Israeli Science Foundation , Sackler School Of Medicinetel Aviv University , Immunology Department Of Tel Aviv University , Natalia Freundassistant Professor , Sackler School , Medicinetel Aviv , Image Credit , Immunology Department , Tel Aviv University , New York City , Assistant Professor , Coronavirus Disease Covid 19 , Antibody Discovery , Hiv 1 ,