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Machine-learning how to create better AAV gene delivery vehicles

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IMAGE: In their machine learning-based capsid diversification strategy, the team focused on a 28 amino acid peptide within a segment of the AAV2 VP3 capsid protein that exposes the AAV capsid.
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Credit: Wyss Institute at Harvard University (original by Drew Bryant)
(Boston) Adeno-associated viruses (AAVs) have become promising vehicles for delivering gene therapies to defective tissues in the human body because they are non-pathogenic and can transfer therapeutic DNA into target cells. However, while the first gene therapy products approved by the Federal Drug Administration (FDA) use AAV vectors and others are likely to follow, AAV vectors still have not reached their full potential to meet gene therapeutic challenges. ....

United States , Boston University , University Of Massachusetts Medical School , Massachusetts Institute Of Technology , United Kingdom , Dana Farber Cancer Institute , Tufts University , Spaulding Rehabilitation Hospital , Ali Bashir , Eric Kelsic , Donald Ingber , Benjamin Boettner , Ninak Jain , Beth Israel Deaconess Medical Center , University Of Cambridge , Google Research , Wyss Institute , Wyss Institute Synthetic Biology , George Church Synthetic Biology , Lucyj Colwell At Google Research , Health Sciences , University Of Zurich , Drug Administration , Professor Of Genetics At Harvard Medical School , Arts Sciences , Harvard Wyss Institute For Biologically Inspired Engineering ,

Study finds even the common house sparrow is declining

Credit: Donald Metzner, courtesy Cornell Lab of Ornithology.
Ithaca, NY The European House Sparrow has a story to tell about survival in the modern world. In parts of its native range in Europe, House Sparrow numbers are down by nearly 60%. Their fate in the U.S. and Canada is less well known. A new study by Cornell Lab of Ornithology scientists aims to clarify the status of this non-native species, using 21 years of citizen science data from the Cornell Lab s Project FeederWatch. The results are published in the
Wilson Journal of Ornithology.
We wanted to find out where and how much House Sparrows might be declining here, explains lead author Liam Berigan, who did this work while at the Cornell Lab and who is now a Ph.D. student at the University of Maine. We also explored whether the declines would match up with an increase in hawk populations, as is true in European studies. Surprisingly, they didn t. ....

United States , National Land Cover , Cornell Lab Of Ornithology , Cornell Lab Project Feederwatch , University Of Maine , Cornell Lab , European House Sparrow , House Sparrow , Wilson Journal , House Sparrows , Liam Berigan , North America , Ecology Environment , Population Biology , ஒன்றுபட்டது மாநிலங்களில் , தேசிய நில கவர் , கார்னெல் ஆய்வகம் ஆஃப் ஆர்‌நிதாலஜீ , பல்கலைக்கழகம் ஆஃப் மைனே , கார்னெல் ஆய்வகம் , ஐரோப்பிய வீடு குருவி , வீடு குருவி , வில்சன் இதழ் , வீடு சிட்டுக்குருவிகள் , வடக்கு அமெரிக்கா , சூழலியல் சூழல் , பாப்யுலேஶந் உயிரியல் ,

Model estimates COVID-19 cases in the U.S. to be three times greater than reported

World health experts have long suspected that the incidence of COVID-19 has been higher than reported. ....

New York , United States , United Kingdom , Jungsik Noh , Emily Henderson , Johns Hopkins University , Lyda Hill Department Of Bioinformatics , Lyda Hill Department , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , லிய்தத மலை துறை ஆஃப் உயிர் தகவலியல் , லிய்தத மலை துறை , உயிர் தகவலியல் , சர்வதேச பரவல் ,

New machine-learning algorithm estimates number of COVID-19 cases in the U.S.

World health experts have long suspected that the incidence of COVID-19 has been higher than reported. Now, a machine-learning algorithm developed at UT Southwestern estimates that the number of COVID-19 cases in the U.S. since the pandemic began is nearly three times that of confirmed cases. ....

New York , United States , United Kingdom , Jungsik Noh , Gaudenz Danuser , Patricke Haggerty , Emily Henderson , Johns Hopkins University , Lyda Hill Department Of Bioinformatics , Lyda Hill Department , Study First Author , Assistant Professor , Distinguished Chair , Basic Biomedical , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , லிய்தத மலை துறை ஆஃப் உயிர் தகவலியல் , லிய்தத மலை துறை , படிப்பு முதல் நூலாசிரியர் , உதவியாளர் ப்ரொஃபெஸர் , புகழ்பெற்ற நாற்காலி , அடிப்படை உயிர் மருத்துவ , உயிர் தகவலியல் ,

Genes that dance to circadian rhythm

Date Time
Genes that dance to circadian rhythm
Scientists at EPFL have made breakthrough discoveries on the circadian clock and how it affects gene expression. Some of the findings suggest a biological underpinning for different behaviors in people, such as morning people, nappers, evening people, night owls etc.
In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the “wake-sleep” cycle. To carry out their work, the scientists used the common fruit fly Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it. ....

Bart Deplancke , Maria Litovchenko , Charlesw Woodworth , Thomash Morgan , School Of Life Sciences , Swiss Institute Of Bioinformatics , Drosophila Genetic Reference Panel , Brandeis University , Fly Room At Columbia University , Nobel Prize , Fly Room , Columbia University , Life Sciences , Science Advances , Circadian Rhythm , Agenetic Mutation , Fruit Flies , தோமாஷ் மோர்கன் , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , சுவிஸ் நிறுவனம் ஆஃப் உயிர் தகவலியல் , பிராண்டீஸ் பல்கலைக்கழகம் , ஈ அறை இல் கொலம்பியா பல்கலைக்கழகம் , நோபல் ப்ரைஸ் , ஈ அறை , கொலம்பியா பல்கலைக்கழகம் , வாழ்க்கை அறிவியல் ,