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Not just a phase for RNAS


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IMAGE: Image shows cells with oil droplet-like NORAD-Pumilio bodies in red and nucleus in blue. Credit: Mahmoud Elguindy
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Credit: Mahmoud Elguindy
DALLAS - June 9, 2021 - A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water, appears to tightly regulate the activity of Pumilio. A new study led by UT Southwestern scientists suggests that such RNA-driven phase separation, in turn, protects against genome instability, premature aging, and neurodegenerative diseases, and may represent a previously unrecognized way for RNAs to regulate cellular processes.
It s becoming more and more clear that phase separation is an important organizing principle in cells, says Joshua Mendell, M.D., Ph.D., professor of molecular biology and a Howard Hughes Medical Institute investigator at UTSW who led the study published online today in ....

United States , F Andrew Bell , Steven Mcknight , Mar Nell , Joshua Mendell , Michael Rosen , Mahmoud Elguindy , National Institutes Of Health , Haroldc Simmons Comprehensive Cancer Center , National Academy Of Medicine , Welch Foundation , National Academy Of Sciences , Scientist Training Program , Howard Hughes Medical Institute , Biomedical Research , National Academy , National Institutes , Comprehensive Cancer , Distinguished Chair , Basic Biomedical , Bell Distinguished Chair , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , எஃப் ஆண்ட்ரூ மணி , ஸ்டீவன் மக்நைட் , மார் நெல் ,

COVID-19 Infections in U.S. Nearly 3X Greater Than Reported, University Model Estimates


COVID-19 Infections in U.S. Nearly 3X Greater Than Reported, University Model Estimates
February 12, 2021
World health experts have long suspected that the incidence of COVID-19 has been higher than reported. Now, a machine-learning algorithm developed at University of Texas Southwestern Medical Center estimates that the number of COVID-19 cases in the U.S. since the pandemic began is nearly three times that of confirmed cases.
The algorithm, described in a study published in PLOS ONE, provides daily updated estimates of total infections to date as well as how many people are currently infected across the U.S. and in 50 countries hardest hit by the pandemic. ....

United States , New York , University Of Texas Southwestern Medical Center , United Kingdom , Jungsik Noh , Gaudenz Danuser , Patricke Haggerty , Johns Hopkins University , Lyda Hill Department Of Bioinformatics , U Texas Southwestern Medical Center , Texas Southwestern Medical Center , Lyda Hill Department , Distinguished Chair , Basic Biomedical , Lyda Hill , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் தென்மேற்கு மருத்துவ மையம் , ஒன்றுபட்டது கிஂக்டம் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , லிய்தத மலை துறை ஆஃப் உயிர் தகவலியல் , உ டெக்சாஸ் தென்மேற்கு மருத்துவ மையம் , டெக்சாஸ் தென்மேற்கு மருத்துவ மையம் , லிய்தத மலை துறை , புகழ்பெற்ற நாற்காலி , அடிப்படை உயிர் மருத்துவ ,