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Scientists map the brain of a nematode worm

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IMAGE: The spatial organisation of the C. elegans brain is modular. The image shows the different brain regions that process information to direct behaviours such as navigation, avoidance and feeding. The.
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Credit: University of Leeds
Researchers have mapped the physical organization of the brain of a microscopic soil-living nematode worm called
Caenorhabditis elegans, creating a new model for the architecture of the animal s brain and how it processes information.
In a surprise twist, they found a large degree of variation in the structure of some neural circuits or pathways in individual worms which complemented a core set of neural circuits common to different animals. ....

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New discoveries on the containment of COVID-19 finds travel bans are of limited value

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BROOKLYN, New York, Wednesday, February 24, 2021 - Travel bans have been key to efforts by many countries to control the spread of COVID-19. But new research aimed at providing a decision support system to Italian policy makers, recently published in the
Journal of the Royal Society Interface, suggests that reducing individual activity (i.e., social distancing, closure of non-essential business, etc.) is far superior in controlling the dissemination of Sars-CoV-2, the virus that causes COVID-19.
The research, which has implications for the United States and other countries, found that limiting personal mobility through travel restrictions and similar tactics is effective only ....

New York , United States , New Rochelle , Alessandro Rizzo , Francesco Parino , Lorenzo Zino , Journal Of The Royal Society Interface , Netherlands Organisation For Scientific Research Nwo Vidi , Maurizio Porfiri Institute Professor , Office Of Innovation , European Research Council , University Of Groningen , Us National Science Foundation , Royal Society Interface , Urban Science , Advanced Modeling , Science Foundation , San Paolo , Netherlands Organisation , Scientific Research , Population Biology , Health Care , Algorithms Models , Medicine Health , Infectious Emerging Diseases , Public Health ,

Management of big data in omics research

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Bioinformatics, and by extension omic sciences - the collective disciplines that are dependent on the use of extensive datasets of biological information - present a challenge of data management for researchers all over the world. Big data collected as part of research projects and experiments can be complex, with several kinds of variables involved. Coupled with continuously changing bioinformatics and information technology tools, there is a need to bring a multidisciplinary approach into these fields.
Advances in Bioinformatics, Biostatistics and Omic Sciences attempts to realize an integrated approach between all omic sciences, exploring innovative bioinformatics and biostatistical methodologies which enable researchers to unveil hidden sides of biological phenomena. ....

Biologiae Genetica , Luigi Donato , Experimental Medicine In University Of Messina , Reviewer Board Of Brain Sciences , Mediterranean Institute Of Science , Statistics Applied To Sciences , Biomic Sciences , Association Of Research , Integrated Mitochondrial , Improve Quality Assessment , Putative Pathogenic Variants , Future Perspectives , Gene Prioritization Pipeline , Integrated Differential Expression Approach , Seq Data Analysis , Data Visualization , Straightforward Interpretation , Nucleic Acid Omics , Molecular Genetics , Euro Mediterranean Institute , Statistics Applied , Organizing Committee , Editorial Board , Guest Editor , Proteomics Open Access , Reviewer Board ,

Basic cell health systems wear down in Huntington's disease, analysis shows | MIT News | Massachusetts Institute of Technology

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Researchers employed a software system called Geomic to integrate vast amounts of gene expression data from the brains of mice modeling Huntington s disease. By comparing multidimensional mathematical surfaces plotted from the data, they were able to gain new insights into how gene expression differs in the disease based on many dimensions such as time, cell type and the extent of mutation in the huntingtin gene.
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Image: Lucile Megret/Sorbonne Universite
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Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage from the disease pathology itself. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , Picower Institute For Learning And Memory , Huntington Amp 039s Disease ,

Largest comprehensive Middle East GWAS reveals Arab genetic risk factors

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IMAGE: Dr. Omar Albagha, one of the principal investigators of Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits , Nature Communications 2021
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Credit: Qatar Foundation
Doha, Qatar - (February 23, 2021) - A group of researchers at Qatar Foundation have reported the first and largest genetic association study in the Middle East, that has been published online in
Nature Communications - a leading a peer-reviewed, open access, scientific journal published by Nature Research.
The study titled Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits highlights a vital piece of information wherein now there is a better understanding of the genetic risk factors that are specific to the Arab population, including those that are shared with other ethnicities. ....

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