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Formula predicts ideal dose of stem cells to cure HIV

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Scientists have determined the optimal conditions following a stem cell transplant that could control HIV without the need of an everyday pill, according to a study published today in
eLife.
Finding the right balance of stem cell dose, cell type and timing of antiretroviral therapy (ART) could potentially lead to a spontaneous cure of HIV.
There are only two cases of HIV cure to date: the Berlin Patient and the London Patient, who both received stem cell transplants with stem cells from donors that lack a molecule called CCR5, which HIV is attracted to.
The major obstacle to HIV eradication is a latent reservoir of long-lived infected cells, and cure strategies aim to eliminate all infected cells or permanently prevent viral reactivation from latency, explains first author E. Fabian Cardozo-Ojeda, Senior Staff Scientist at the Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, US. We wanted to recreate the cur ....

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Like plants do: non-classical photosynthesis by earth's inorganic semiconducting minerals

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IMAGE: Earth-abundant minerals convert sunlight into chemical energy, hinting at the evolution of photosynthesis in early bacteria
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Credit: Earth Science Frontiers
Photosynthesis, the process by which plants and other organisms convert sunlight into chemical energy, has been a major player during the evolution of life and our planet s atmosphere. Although most of the ins and outs of photosynthesis are understood, how the necessary mechanisms evolved is still a topic of debate. The answer to this question, however, may actually lie buried in the mineral world.
In a recent study published in Earth Science Frontiers (10.13745/j.esf.sf.2020.12.3), scientists from Peking University, China, shifted the focus in photosynthesis research from plants and bacteria one step further back to rocks and substances found in what s known as the mineral membrane of Earth. They propose that various components of this relatively thin layer, such as bir ....

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Broad Institute and Verily partner with Microsoft to accelerate next generation of Terra platform for health and life science

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Broad Institute and Verily partner with Microsoft to accelerate next generation of Terra platform for health and life science
Multiyear partnership brings together advanced technology, industry expertise and scale to help researchers interpret an unprecedented amount of biomedical data and derive insights to advance the treatment of human diseases
CAMBRIDGE, Mass., SOUTH SAN FRANCISCO, Calif., and REDMOND, Wash. – Jan. 11, 2021 – On Monday, Broad Institute of MIT and Harvard, Verily, an Alphabet company, and Microsoft Corp. announced a strategic partnership to accelerate new innovations in biomedicine through the Terra platform. Terra, originally developed by Verily and the Broad Institute, is a secure, scalable, open-source platform for biomedical researchers to access data, run analysis tools and collaborate. Terra is actively used by thousands of researchers every month to analyze data from millions of participants in important scientific re ....

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Landmark human study is first to reveal strong links between gut microbes, diet and health

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Diets rich in certain plant-based foods are linked with the presence of gut microbes that are associated with a lower risk of developing conditions such as obesity, type 2 diabetes and cardiovascular disease, according to recent results from a large-scale international study that included researchers from King s College London, the Harvard T.H. Chan School of Public Health, Massachusetts General Hospital (MGH), the University of Trento, Italy, and health science start-up company ZOE.
Key Takeaways
The largest and most detailed study of its kind uncovered strong links between a person s diet, the microbes in their gut (microbiome) and their health. ....

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COVID-19 genome sequencing project gets major upgrade

Supercomputing facilities set up to track the spread and evolution of the COVID-19 pandemic have received £1.2m in government funding to expand. ....

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