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Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.
<p>Traumatic brain injuries (TBIs) can cause lasting damage, but stopping the rampant brain inflammation they cause is difficult. A team at the Wyss, @SEAS and @MGH led by Samir Mitragotri has made a new treatment using macrophages - immune cells that migrate to the brain. By attaching microparticle "backpacks" that kept the macrophages in a healing state, they reduced the size of brain lesions by 56% in pigs with a mock TBI.</p>
<p>We all know someone who's had a head injury that was "only" a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children's Hospital created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body's own immune cells called macrophages. They attached microparticle "backpacks" containing a common MRI contrast agent to the cells, which migrated...
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