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Why Consumers Should Care About Biomarkers — And How Technology Developers and Manufacturers Can Bridge the Gap

More precise and consumer-friendly biomarker detection technologies are coming to market at a pace that can help users gain rich insight into their health and well-being from anywhere and at any time. This is especially important when it comes to preventive healthcare. ....

Weight Loss , Medical Devices , Healthcare Innovation , Medcity News , Medcity News , San Francisco , Life Sciences , Rock Health , Startup Advice , Startup Funding , Patient Monitoring System , Otion Sensors , Healthcare It , Foodborne Pathogens , Iagnostics Company , Iagnostic Platforms , Minimally Invasive Surgery , Aser Surgery , Ealth And Wellness , Mployee Wellness Programs , Hanghai Innovation Center , R D , Twin Cities , Ulcerative Colitis , Abbott Labs , Abbott Labs ,

Researchers identify biomarkers for checkpoint inhibitor-induced hyperprogression of melanoma cells

Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them. ....

Tarek Haykal , Balamayooran Theivanthiran , Nagendra Yarla , Aprilks Salama , Michaelp Plebanek , Y Van Nguyen , Nicholasc Devito , Alisha Holtzhausen , April Salama , Brent Hanks , Linda Cao , Michelle Ferreira , National Institutes Of Health , Duke Cancer Institute , Duke Health , Cancer Institute , Science Translational , Associate Professor , Duke University School , Rami Al Rohil , National Institutes , Immune System , Melanoma Cells ,

Antiamyloid Gantenerumab Disappoints in Phase 3 Trials

The antiamyloid monoclonal antibody gantenerumab led to a lower amyloid plaque burden but no clear cognitive benefit in early Alzheimer s disease in twin pivotal trials. ....

Washington University , United States , Genentech Roche , Randallj Bateman , Howard Fillit , Alzheimer Drug Discovery Foundation , Washington University School Of Medicine , Medscape Medical , New England Journal , Clinical Dementia Rating , Washington University School , Promising Pipeline , Medscape Medical News , Drug Discovery Foundation , Alzheimers Disease , Lzheimer Disease , Antidementia Agents , Amyloid Plaque , Biologic Therapy , Mild Cognitive Impairment , Iological Marker , Drug Development , Monoclonal Antibody , Cognitive Impairment , Amyloid Beta ,

White House Appoints New NCI Director

After years of working with the National Cancer Institute, W. Kimryn Rathmell, MD, PhD, gets the call to run the institute. ....

United States , White House , District Of Columbia , W Kimryn Rathmell , Joe Biden , Monica Bertagnolli , Margaret Foti , Clifford Hudis , Cancer Genome Atlas Program , American Society Of Clinical Oncology , American Association For Cancer Research , National Academy Of Medicine , National Institutes Of Health , American Academy Of Arts , Vanderbilt University Medical Center , National Cancer Institute , National Institutes , New England Journal , Scientific Advisors , Genome Atlas , American Society , Clinical Oncology , American Association , Cancer Research , National Academy , American Academy ,

"A clinically useful and biologically informative genomic classifier fo" by Steven Craig, Cynthia Stretch et al.

Clinical management of papillary thyroid cancer depends on estimations of prognosis. Standard care, which relies on prognostication based on clinicopathologic features, is inaccurate. We applied a machine learning algorithm (HighLifeR) to 502 cases annotated by The Cancer Genome Atlas Project to derive an accurate molecular prognostic classifier. Unsupervised analysis of the 82 genes that were most closely associated with recurrence after surgery enabled the identification of three unique molecular subtypes. One subtype had a high recurrence rate, an immunosuppressed microenvironment, and enrichment of the EZH2-HOTAIR pathway. Two other unique molecular subtypes with a lower rate of recurrence were identified, including one subtype with a paucity of BRAFV600E mutations and a high rate of RAS mutations. The genomic risk classifier, in addition to tumor size and lymph node status, enabled effective prognostication that outperformed the American Thyroid Association clinical risk stratific ....

United States , American Thyroid Association , Cancer Genome Atlas Project , Machine Learning , Papillary Thyroid Cancer , Risk Stratification ,