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Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Despite treatment, GBM recurrence is inevitable and tends to occur outside surgical margins or in locations remote to the primary tumor, highlighting the central role played by tumor infiltration in this malicious disease.
Researchers at Baylor College of Medicine and collaborating institutions have uncovered novel aspects of astrocyte function in olfactory, or smell, perception revealing changes in their gene expression patterns that turn these brain cells into a hub of olfactory sensation processing.
E-Mail Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner. Researchers found that female mice with glioma that lacked the gene survived less than males. This led them to investigate human glioma cells, where they found that low POT1 expression correlated with reduced survival in females. Published in the journal Cancer Research, the study also shows that, compared to males', female tumors ha...