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Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner. Researchers found that female mice with glioma that lacked the gene survived less than males. This led them to investigate human glioma cells, where they found that low POT1 expression correlated with reduced survival in females.
Published in the journal
Cancer Research, the study also shows that, compared to males , female tumors had reduced expression of immune signatures and increased expression of cell replication markers, suggesting that the immune response and tumor cell proliferation seemed to be involved in favoring tumor growth. ....

Stanford University , United States , Baylor College Of Medicine , San Diego , Kathleen Kong , Matthew Bainbridge , Navish Bosquez Huerta , Kwanha Yu , Vivekb Beechar , Benjamin Deneen , Ganesh Rao , Anthony Grichuk , Deepika Mehra , Brittney Lozzi , Mariank Blattner , Kenneth Scott , Ali Jalali , Melissa Bondy , National Cancer Institute , Researchers At Baylor College Of Medicine , Rob Rutherford Glioblastoma Research Postdoctoral Fellowship , Cancer Research , Danl Duncan Comprehensive Cancer Center , American Cancer Society , Baylor College , Texas Children ,