POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner
E-Mail Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner. Researchers found that female mice with glioma that lacked the gene survived less than males. This led them to investigate human glioma cells, where they found that low POT1 expression correlated with reduced survival in females. Published in the journal Cancer Research, the study also shows that, compared to males', female tumors ha...
Source: eurekalert.org