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Light show in living cells

<p>Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge - especially in living cells, as the required fluorescent labelling had to be individually attached to each protein. The research group led by Stefan Kubicek at CeMM has now overcome this hurdle: With a method called &quot;vpCells,&quot; it is possible to label many proteins simultaneously, using five different fluorescent colours. This automated high-throughput approach, aided by AI-assisted image recognition, opens up entirely new applications in various disciplines, from fundamental cell biology to drug discovery. The study has been published in the journal <em>Nature Cell Biology</em> (DOI: 10.1038/s41556-024-01407-w), and the related images are available at <em>vpcells.cemm.at</em>.</p>


Italy , Austria , Zurich , Züsz , Switzerland , Vienna , Wien , Austrian , Stuart-schreiber , Maria-ciobanu , Marton-siklos , Viktoriia-kartysh

New insights into immune system role in lung cancer risk

New insights into immune system role in lung cancer risk
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Hebron , Israel-general- , Israel , Helsinki , Eteläuomen-läi , Finland , Hamburg , Germany , New-york , United-states , Stony-brook , Massachusetts

Study Reveals New Insights Into Immune System Role in Lung Cancer Risk

Recent developments in cancer research have highlighted the vital role of the immune system, particularly in the notable successes of cancer immunotherapy. Now,

Massachusetts , United-states , Brooklyn , New-york , United-kingdom , Stony-brook , Helsinki , Eteläuomen-läi , Finland , Hebron , Israel-general- , Israel

Study reveals new insights into immune system

<p style="text-align:justify">Recent developments in cancer research have highlighted the vital role of the immune system, particularly in the notable successes of cancer immunotherapy. Now, a paradigm-shifting study&nbsp;led by researchers at the Icahn School of Medicine at Mount Sinai in New York in collaboration with the University of Helsinki and Massachusetts General Hospital sheds light on how variations in immune genetics influence lung cancer risk, potentially paving the way for enhanced prevention strategies and screening. The findings were described in the February 22 online issue of<em>&nbsp;</em><a href="http://www.science.org/doi/10.1126/science.adi3808"><em>Science</em></a><em>.</em></p>

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Hamburg , Germany , Hebron , Israel-general- , Israel , Morningside , North-lanarkshire , United-kingdom , Barcelona , Comunidad-autonoma-de-cataluna , Spain , Helsinki

Pairwise Shares Updated Strategy to Deliver High-Impact

Following Introduction of First CRISPR Food to North American Market, Strategic Focus Enables Company to Accelerate Innovation in Food and Agriculture...

United-states , American , Feng-zhang , Tom-adams , J-keith-joung , Vonnie-estes , David-liu , Pairwise-co , Temasek , Merkin-institute-of-transformative-technologies-in-healthcare , Broad-institute-of-harvard , International-fresh-produce-association

Pairwise Shares Advantages of Company-Developed Fulcrum™ Platform

Pairwise Shares Advantages of Company-Developed Fulcrum™ Platform
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United-states , America , Tom-adams , J-keith-joung , Ryan-bartlett , Ian-miller , Feng-zhang , David-liu , Merkin-institute-of-transformative-technologies-in-healthcare , Broad-institute-of-harvard , Development-officer , Technology-officer

Noninvasive technique reveals how cells' gene expression changes over time

Noninvasive technique reveals how cells' gene expression changes over time
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Japan , Koseki-kobayashi-kirschvink , Jeon-woong-kang , Jian-shu , Tommaso-biancalani , Aviv-regev , Us-national-institutes-of-health , Helen-hay-whitney-foundation , Early-development , Genentech-research , Department-of-biology , Broad-institute-of-harvard

Noninvasive Method Uncovers Gene Expression Changes Over Time

Noninvasive Method Uncovers Gene Expression Changes Over Time
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Japan , Aviv-regev , Tommaso-biancalani , Koseki-kobayashi-kirschvink , Jeon-woong-kang , Jian-shu , Naito-foundation-overseas-postdoctoral-fellowship , Us-national-institutes-of-health , Howard-hughes-medical-institute , Laser-biomedical-research-center , Early-development , Department-of-biology

Noninvasive Method Unveils Changes in Cells' Gene Expression Over Time

Noninvasive Method Unveils Changes in Cells' Gene Expression Over Time
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Cambridge , Cambridgeshire , United-kingdom , Tommaso-biancalani , Aviv-regev , Jeon-woong-kang , Jian-shu , Koseki-kobayashi-kirschvink , Department-of-biology , Early-development , Broad-institute-of-harvard , Broad-institute

Noninvasive technique reveals how cells' gene expression changes over time | MIT News | Massachusetts Institute of Technology

A new method can track changes in live cell gene expression over extended periods of time. Based on Raman spectroscopy, the method doesn’t harm cells and can be performed repeatedly.

Japan , Tommaso-biancalani , Koseki-kobayashi-kirschvink , Jian-shu , Aviv-regev , Jeon-woong-kang , Broad-institute-of-harvard , Genentech-research , Us-national-institute-of-biomedical-imaging , Helen-hay-whitney-foundation , Harvard-medical-school , Naito-foundation-overseas-postdoctoral-fellowship