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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
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The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Among the most promising therapeutic options for individuals with coronavirus disease 2019 (COVID-19) are monoclonal antibodies (mAbs). In this study, Jones et al . identified, characterized, and tested one such mAb, LY-CoV555, in vitro and in vivo. They found that LY-CoV555 bound to the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) spike protein and prevented its interaction with angiotensin-converting enzyme 2. Prophylactic treatment with LY-CoV555 protected the upper and lower respiratory tracts of nonhuman primates from becoming infected with SARS-CoV-2. Together, these data support the clinical use of LY-CoV555 for treating patients with COVID-19.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may bridge widespread vaccination campaigns and offer a treatment solution in populations le ....

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Duke scientists develop new potential coronavirus vaccine – it's already effective in animal studies

by Sarah Avery May 10, 2021 .
DURHAM – A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections – including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic.
The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body’s cell receptors, and is formulated with a chemical booster called an adjuvant. Success in primates is highly relevant to humans. ....

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New vaccine blocks COVID-19 and variants, plus other coronaviruses

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DURHAM, N.C. - A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic.
The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body s cell receptors and is formulated with a chemical booster called an adjuvant. Success in primates is highly relevant to humans. ....

South Africa , State Of North Carolina , North Carolina , United States , United Kingdom , University Of North Carolina , Rachell Spreng , C Todd Demarco , Mahnaz Minai , Surender Khurana , Thomash Oguin , Kartik Manne , Sophie Gobeil , Elizabethw Petzold , S Munir Alam , Matthew Gagne , Markg Lewis , Diann Moore , Hanne Andersen , Fangping Cai , Kevin Saunders , Davidr Martinez , Longpingv Tse , Robertj Edwards , Laural Sutherland , Christopherb Fox ,