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Sustained endurance exercise in athletes, footballers and other sportspeople can lead to the development of abnormal heart rhythms.

The study, published in the leading journal  Circulation Research, found that long-term training in both horses and mice caused a reduction in key proteins, known as ion channels, that control AV node conduction. The expression and activity of the ion channels were then investigated in detail in mice that followed a program which modelled long-term exercise training to build their fitness. The mice were used to explore mechanisms underlying heart block in detail using approaches that would not be possible in racehorses. Training-induced heart block and underlying ion channel changes were re...

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis. The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of V...

Researchers identify heart block cause in athletes While heart block is benign for most people, it can be a precursor to more serious heart problems. 23 June, 2021 23:01 Why some endurance athletes experience a heart rhythm disturbance called heart block has been identified by researchers using animal models. The University of Manchester-led study found that long-term exercise in retired racehorses – the best available model of the athlete’s heart – and in mice, triggered molecular changes in a part of the heart known as the atrioventricular (or AV) node. ...

Oday we bring you a shocking true story about covid-19 vaccines, the government of Connecticut, and an open admission that vaccines contain dangerous, even deadly substances (spike proteins) that are documented and known to cause vascular damage to human beings. It’s all admitted right in the open, in these Connecticut government documents shown below, which […]