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Gene Therapy for Dementia? COVID Vaccine and MS; Four Patterns of Tau

Six dementia patients received a controversial gene therapy injection in Mexico City, according to a biotech CEO.
(STAT)
(Nature)
Cladribine (Mavenclad) did not impair humoral response to COVID-19 vaccination in patients with multiple sclerosis (MS), but ocrelizumab (Ocrevus) and fingolimod (Gilenya) did, a small study in Israel showed.
(Therapeutic Advances in Neurological Disorders)
Median SARS-CoV-2 antibody response was lower for MS patients on ocrelizumab than it was for other MS patients with COVID-19.
(JAMA Neurology)
An investigational Alzheimer's treatment known as BPN14770, a phosphodiesterase-4D inhibitor, boosted cognition in a phase II trial of people with fragile X syndrome.
(Nature Medicine)

Mexico-city , Distrito-federal , Mexico , New-york , United-states , Environmental-protection-agency , District-of-columbia , Israel , Washington , Judy-george , Cladribine-mavenclad , New-york-times

'Laverne & Shirley' Star's Death

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Actor David Lander, known for his role as Andrew "Squiggy" Squiggman on the sitcom "Laverne & Shirley," died at the age of 73 at Cedars-Sinai Medical Center in Los Angeles, from complications of multiple sclerosis. In a statement to
CNN, "David's family hopes his fans will remember him for all the laughter he brought into the world."
Lander was originally diagnosed with multiple sclerosis in 1984, a year after "Laverne & Shirley" ended its 8-year run. He began to experience dizziness and numbness in his hands and feet. A spinal tap revealed his diagnosis, but he kept it a secret to all but his family, as he thought it would end his career in Hollywood. In 1999, he publicly revealed his diagnosis in a memoir entitled, "Fall Down Laughing: How Squiggy Caught Multiple Sclerosis and Didn't Tell Nobody." In 2000, the National MS Society named Lander one of their National Ambassadors. He toured the country and became an advocate for patients with MS, speaking at conventions and fundraisers.

Hollywood , California , United-states , Cladribine-mavenclad , Teriflunomide-aubagio , Siponimod-mayzent , Michelle-obama , Fingolimod-gilenya , Alemtuzumab-lemtrada , Los-angeles , Andrew-squiggy-squiggman , Laverne-shirley