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DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair facto...

The Dragonfly 600 confocal microscope from Andor Technology Ltd. allows users to image live specimens for days without phototoxicity or photobleaching

Oxford Instruments Andor has launched Dragonfly 600, further strengthening its renowned confocal microscopy portfolio

High-temperature laser-scanning confocal microscopy (HT-LSCM) has proven to be an excellent experimental technique through in situ observations of high temperature phase transformation to study kinetics and morphology using thin disk steel specimens. A 1.0 kW halogen lamp within the elliptical cavity of the HT-LSCM furnace radiates heat and imposes a nonlinear temperature profile across the radius of the steel sample. When exposed at the solid/liquid interface, this local temperature profile determines the kinetics of solidification and phase transformation morphology. A two-dimensional numeri...

The BC43 is a benchtop confocal microscope that is a super-compact unit that is rich in features and benefits, making it the ideal microscope for early-stage researchers and experienced microscopists alike.