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Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs. Design Systematic review and meta-analysis. Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of unpublished and international literature (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, ProQuest Dissertations and Theses Global, and PsycEXTRA), and handsearching of reference l...

A meta-analysis of 12 trials suggests catheter ablation for atrial fibrillation reduces heart failure events in HFrEF patients but not in HFpEF.

Statin therapy modestly increases diabetes diagnoses but offers substantial cardiovascular benefits, outweighing the slight rise in glycemia, especially in those near diabetes diagnostic thresholds.

In patients with DOAC use within 48 hours of a stroke, intravenous thrombolysis does not increase risk for hemorrhagic complications.

In patients with DOAC use within 48 hours of a stroke, intravenous thrombolysis does not increase risk for hemorrhagic complications.