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Persistent obstructive sleep apnoea in children: treatment options and management considerations

Unresolved obstructive sleep apnoea (OSA) after an adenotonsillectomy, henceforth
referred to as persistent OSA, is increasingly recognised in children (2–18 years).
Although associated with obesity, underlying medical complexity, and craniofacial
disorders, persistent OSA also occurs in otherwise healthy children. Inadequate treatment
of persistent OSA can lead to long-term adverse health outcomes beyond childhood.
Positive airway pressure, used as a one-size-fits-all primary management strategy
for persistent childhood OSA, is highly efficacious but has unacceptably low adherence
rates. ....

Cameroon General , United States , Acta Otolaryngol , Gerry Taylor , Strollo Jr , Balkissou Adamou , Pediatr Pulmonol , J Pediatr Otorhinolaryngol , Li Xinjun , J Orthod Dentofacial Orthop , American Heart Association , Paediatr Child Health , National Sleep Foundation , Lancet Digit Health , Englj Med , Head Neck Surg , Down Syndrome , Digit Health , American Heart , Clin Sleep Med , Respir Rev , Med Clin , Brain Res , Jappl Physiol , Child Health , Med Eng Technol ,

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-II)

Although phase 2 data suggested baricitinib as a potential treatment for patients
with SLE, which was supported in SLE-BRAVE-I, this result was not replicated in SLE-BRAVE-II.
No new safety signals were observed. ....

American College Of Rheumatology , Rev Rheumatol , Res Ther , Englj Med , Rheum Dis , Database Syst Rev , Biol Med , Rev Drug Discov , Sci Med , American College , Rev Clin Immunol ,

Directly observed therapy

“it was all about standing alone
in a big grey city
and somebody suddenly
handing you marigolds”
The Lift (2013), Janis Freegard ....

United States , Glob Public Health , Public Health , Database Syst Rev ,

Studies show supplements have mixed results combatting common cold

The common cold is responsible for 150 million missed workdays annually in the United States. Many of us will head to the nutrition supplement aisle to ward off these nasty viruses, but do these supp… ....

United States , Leanne Mccrate , Dear Dietician , Gonzales Weekly , Elderberry Supplementation Reduces Cold Duration , Double Blind Placebo Controlled Clinical , Database Syst Rev , Dear Dietitian ,

Systemic sclerosis

Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue
disease. Once considered an untreatable and unpredictable condition, research advancements
have improved our understanding of its disease pathogenesis and clinical phenotypes
and expanded our treatment armamentarium. Early and accurate diagnosis is essential,
while ongoing efforts to risk stratify patients have a central role in predicting
both organ involvement and disease progression. A holistic approach is required when
choosing the optimal therapeutic strategy, balancing the side-effect profile with
efficacy and tailoring the treatment according to the goals of care of the patient. ....

Ma An , United States , United Kingdom , Sri Lanka , France General , J Clin Rheumatol , Respir Pulm , Semin Hematol , Almeida Chaves , Chemother Pharmacol , Coll Cardiol , Matucci Cerinic , Los Angeles , Clin Rheumatol , J Clin Gastroenterol , Acta Gastroenterol Latinoam , Medsger Jr , Scandj Gastroenterol , Scleroderma Intervention Network , Canadian Scleroderma Research Group , Scleroderma Clinical Trials Consortium Gastrointestinal Tract , International Scleroderma Renal Crisis Study , Eurj Health Econ , International Scleroderma Renal Crisis , Research Group , European Reference Network ,