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and explosions and sirens burglary throughout the night as palestinian fire rockets in response to deadly air strikes. we'll go live to southern israel for more on the escalating tensions. well, the crucial part of president biden's ledgislative agenda appears to be closing in on the closing line. it's set to begin today in the senate. the so-called inflation reduction act includes a $369 billion investment in energy and climate programs. it's the largest in u.s. history. the democrats are still waiting to find out if they can even pass this with a simple party line vote. and it al...

That, that if you administer it in a different way for example invuvenous versus subcutaneous, you can get a comparable response at maybe one-fifth of the dose. so i think it's something worth pursuing. whether they're actually going to be able to do that, i'll leave that up to the fda. but up to approach that as an alternative way, i very much am in favor of. >> well, in the meantime lines to get the vaccine are very long. and there are concerns over both the lack of supply and the lack of urgency. here's cnn's david coalver. >> reporter: we started early just before 6 a.m., our destination f...