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Neuropeptide released by pain neurons promotes wound healing by interacting with immune system

Wound healing is a highly specialized dynamic process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and a chronic state which is more susceptible to infections. Researchers from Monash University in Australia and Osaka University in Japan have demonstrated that the removal of a specific subtype of sensory neurons containing the Nav1.8+ ion channel significantly impairs skin wound repair and muscle regeneration following injury.

Monash , South-australia , Australia , Osaka , Japan , Monash-university , Osaka-university , Bioworld-science , Dermatologic , Calcitonin-gene-related-peptide , Cgrp

Australian researchers discover gene mutation that causes psoriasis

Scientists from the Australian National University have discovered the gene mutation responsible for causing psoriasis, and the findings could lead to improved diagnosis and treatment for patients with psoriasis and psoriatic arthritis, a chronic inflammatory skin disease. “We were able to identify the gene that could be important in enabling this progression from a skin-only condition to a skin-and-joint condition,” lead study author Chelisa Cardinez told BioWorld.

Australia , Australian , Chelisa-cardinez , Australian-national-university , Psoriasis , Psoriatic-arthritis , Ikbkb-gene , Nf-κb-signaling-pathway , Dermatologic , Inflammatory , Immune , Bioworld-science

Rapt slapped with phase II hold on CCR4 prospect

On the verge of top-line data from its phase IIb trial with oral small-molecule CC chemokine receptor 4 (CCR4) antagonist zelnecirnon in atopic dermatitis (AD), due around the middle of this year, Rapt Therapeutics Inc. said the U.S. FDA has imposed a clinical hold on that study with the otherwise promising drug, also known as RPT-193, in AD as well as the phase IIa trial with the same compound in asthma.

Rapt-therapeutics-inc , Rapt-therapeutics , Rapt-therapeutics-inc- , Zelnecirnon , Rpt-193 , Atopic-dermatitis , Asthma , Clinical-hold , Bioworld , Clinical , Respiratory

Kalvista's oral hereditary angioedema drug hits phase III goals

Kalvista Pharmaceuticals Inc. is promising to “change the paradigm” in the treatment of hereditary angioedema, after announcing positive phase III data for its oral on-demand kallikrein inhibitor sebetralstat. Rather than waiting four to five hours to self-administer therapy, as is the case for approved injectable on-demand therapies, there was a median time to dosing of 10 minutes after the start of an attack in the 136-patient placebo-controlled trial.

Kalvista-pharmaceuticals-inc , Kalvista-pharmaceuticals , Kalvista-pharmaceuticals-inc- , Oral-kallikrein-inhibitor , Sebetralstat , Hereditary-angioedema , On-demand , Hae-attacks , Bioworld , Clinical , Dermatologic

Dermasensor granted FDA clearance for skin cancer ID

Dermasensor Inc. received U.S. FDA clearance for its non-invasive skin cancer evaluation device that provides quantitative identification of all skin cancer types at the point of care and within seconds. The point-and-click device is designed to facilitate detection of skin cancers by primary care physicians (PCPs) and speed the time to diagnosis and treatment.

Dermasensor-inc , Bioworld-medtech , Dermasensor-inc- , Elastic-scattering-spectroscopy , Dermatologic , Cancer , Diagnostics , Fda , Regulatory ,

Lirentelimab out on failed phase II data; Allakos restructures

Allakos Inc. terminated all development of its lead drug, anti-Siglec-8 antibody lirentelimab (AK-002), and is cutting its workforce in half, following phase II failures for atopic dermatitis and chronic spontaneous urticaria. The San Carlos, Calif.-based company will now focus on phase I trials for anti-Siglec-6 antibody AK-006 as part of a restructuring that stretches the runway into mid-2026. Shares (NASDAQ:ALLK) sank by 60.2%, down $1.80, to close at $1.19 on Jan. 16.

Allakos-inc , Nasdaq , San-carlos , Allakos-inc- , Lirentelimab , Ak-002 , Atopic-dermatitis , Chronic-spontaneous-urticaria , Restructuring , Ak-006 , Bioworld

JAK Inhibitors Are Revolutionizing Dermatology Field, Says Dr Mona Shahriari

Janus kinase (JAK) inhibitors are not only efficacious in terms of skin disease improvement, but also in terms of itch management, explained Mona Shahriari, MD, assistant clinical professor of dermatology at Yale University and associate director of clinical trials at Central Connecticut Dermatology.

Yale-university , Connecticut , United-states , Mona-shahriari , Central-connecticut-dermatology , Clinical-dermatology-conference , Case-conversations , Fall-clinical-dermatology , Jak-inhibitor , Itch , Dermatologic ,

The Five

you're talking from a position of strength. it looks like a bi g like a baseball flying across the sky, basically. do you thinkhi ink yout could py be a baseball? my guess.ll no., i don't think it's baseball. my guess is that it's some drone like. yeah, it's like there's usually an explanation. there is .on. i am so sick of these stupid sit sightings. >> it's like, imagine you had a dermatologist like this. we found b it a udoh, an unidentified dermatologic object on your back .w we don't know what it is .. shut up.ow don't tell me about it if you don't know what it is . >>ut up. up next, talk about a massive screw up. >> millionabout s of floridarest residents getting a rudein awakening at four forty five in the morning. after a test of the emergency alert system accidentally got sent to folks phones. it was supposed to runes. on television and televisions of was off.f, y but you didn't get it on . you got it. but instead, i got one of these jerko. >> oh, so, yeah, okay.

Baseball , Guess , Drone , Bi-g , Ink-yout , Position , Py , Strength , Baseball-flying , Sky , Guess-ll , Back