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The Clinical and Laboratory Standards Institute Announces the Publication of New Antimicrobial Susceptibility Testing Documents CLSI M100-Ed34, M02-Ed14, and M07-Ed12

The Clinical and Laboratory Standards Institute Announces the Publication of New Antimicrobial Susceptibility Testing Documents CLSI M100-Ed34, M02-Ed14, and M07-Ed12
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Jane Berger , Jamess Lewis , Laboratory Standards Institute , Performance Standards , Antimicrobial Susceptibility Testing , Antimicrobial Disk Susceptibility Tests , Dilution Antimicrobial Susceptibility Tests , Grow Aerobically , Laboratory Standards ,

A novel antibiotic class targeting the lipopolysaccharide transporter

Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options1. No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years1. Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. A clinical candidate derived from the MCP class, zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CRAB both in vitro and in mouse models of infection, overcoming existing antibiotic resistance mechanisms. This chemical class represents a promising treatment paradigm for patients with invasive infections due to CRAB, for whom current treatment option ....

United States , Perifereia Voreiou Aigaiou , Infectious Diseases Society Of America , European Society Of Clinical Microbiology , Drug Administration , Infectious Diseases Society Of America Guidance , Laboratory Standards Institute , European Society , American Thoracic Society , Centers For Disease , Disease Control , European Economic Area , Carbapenem Resistant Acinetobacter , Diseases Society , America Guidance , Clinical Microbiology , Infectious Diseases , Infectious Diseases Society , American Thoracic , Dilution Antimicrobial Susceptibility Tests , Bacteria That Grow Aerobically , Antimicrobial Susceptibility Testing , Determining Bactericidal Activity , Antimicrobial Agents , Acids Res ,