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Welcome To IANS Live - SCIENCE AND TECHNOLOGY - Novel gene editor to correct disease-causing mutations

One in seventeen people in the world suffers from some type of genetic disorder. ....

India Private , News Service , C Tog Base Editor , All Rights , இந்தியா ப்ரைவேட் , செய்தி சேவை , அனைத்தும் உரிமைகள் ,

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain
Mar 12 2021
The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain.
The 2020 Chemistry Nobel Prize-winning technology CRISPR/Cas9 holds great promise for treating various diseases such as congenital disorders and viral infections, by correcting the disease-specific genomic sequences.
This technology attracted increasing attention in the last decade as it allows easy targeting of genomic sequences with high precision and low level of undesired off-target gene editing. However, safe and efficient delivery of the Cas9 DNA cutting enzyme and guide RNA (gRNA), which is a short piece of RN ....

Saed Abbasi , Kazunori Kataoka , Kyoto Prefectural University Of Medicine , Innovation Center , Deputy Principal Research Scientist Dr , Deputy Principal Research Scientist , Satoshi Uchida , Associate Professor , Kyoto Prefectural University , Director General , Nobel Prize Winning , Genome Editing , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் ஆஃப் மருந்து , கண்டுபிடிப்பு மையம் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி டாக்டர் , துணை ப்ரிந்ஸிபல் ஆராய்ச்சி விஞ்ஞானி , சதோஷி உசிதா , இணை ப்ரொஃபெஸர் , கியோட்டோ ப்ரிஃபெக்சரல் பல்கலைக்கழகம் , இயக்குனர் ஜநரல் , நோபல் ப்ரைஸ் வென்றது , மரபணு திருத்துதல் ,

Newly-discovered bat coronavirus 94.5% identical to SARS-CoV-2

Researchers in China and Australia have reported the discovery of novel bat coronaviruses that further reveal the diversity and complex evolutionary history of these viruses. ....

Republic Of , Weifeng Shi , Sally Robertson , Shandong First Medical University , Shandong Academy , Medical Sciences , Southeast Asia , Middle East , Image Credit , South Lao , Corona Virus , Sars Cov 2 , Coronavirus Disease Covid 19 , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , குடியரசு ஆஃப் , சாலி ராபர்ட்சன் , சாண்டோங் முதல் மருத்துவ பல்கலைக்கழகம் , சாண்டோங் கலைக்கழகம் , மருத்துவ அறிவியல் , தென்கிழக்கு ஆசியா , நடுத்தர கிழக்கு , படம் கடன் , தெற்கு லாவோ ,

Whole genome sequencing may guide blood cancer treatment

Whole genome sequencing may guide blood cancer treatment
For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes.
Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades.
Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addition, results can be returned to patients in just a few days, making whole genome sequencing a potentially viable approach for determining the best treatment regimen for a parti ....

Ericj Duncavage , Mollyc Schroeder , Peter Campbell , Davidh Spencer , Emily Henderson , Mcdonnell Genome Institute , Washington University , Siteman Cancer Center At Barnes , Wellcome Sanger Institute In Cambridge , Washington University School Of Medicine , Siteman Cancer Center , Department Of Pathology Immunology , Washington University School , New England Journal , Study Senior Author , Assistant Professor , Medical Director , Clinical Sequencing Facility , Mcdonnell Genome , Barnes Jewish Hospital , Siteman Cancer , Wellcome Sanger Institute , Blood Cancer , Whole Genome Sequencing , Acute Myeloid Leukemia , Bone Marrow ,

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders
A team of researchers from the Agency for Science, Technology and Research s (A STAR) Genome Institute of Singapore (GIS) have developed a CRISPR-based gene editor, C-to-G Base Editor (CGBE), to correct mutations that cause genetic disorders. Their research was published in
Nature Communications on 2 March 2021.
One in seventeen people in the world suffers from some type of genetic disorder. Chances are, you or someone you know - a relative, friend, or colleague - is one of approximately 450 million people affected worldwide. Mutations responsible for these disorders can be caused by multiple mutagens - from sunlight to spontaneous errors in your cells. The most common mutation by far is the single-based substitution, in which a single-base in the DNA (such as G) is replaced by another base (such as C). Countless cystic fibrosis patients worldwide have C instead of G, leading to ....

Kwei Leong , Emily Henderson , Agency For Science , Genome Institute Of Singapore , Nature Communications , Senior Research Scientist , Genome Institute , C Tog Base Editor , Chew Wei Leong , Young Scientist Award , Patrick Tan , Executive Director , Cystic Fibrosis , Genetic Disorder , வெய் லியோங் , எமிலி ஹென்டர்சன் , மரபணு நிறுவனம் ஆஃப் சிங்கப்பூர் , இயற்கை தகவல்தொடர்புகள் , மூத்தவர் ஆராய்ச்சி விஞ்ஞானி , மரபணு நிறுவனம் , மெல் வெய் லியோங் , இளம் விஞ்ஞானி விருது , பேட்ரிக் பழுப்பு , நிர்வாகி இயக்குனர் , சிஸ்டிக் ஃபைப்ரோஸிஸ் , ஜெநெடிக் கோளாறு ,