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Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible

Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible
The B.1.1.7 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant was initially found in England last fall and has quickly overtaken to become the dominant coronavirus strain in the United Kingdom (UK).
The variant’s ability to increase transmission and severe infections has proven to be a challenge for public health officials looking to limit the spread.
New research led by Thushan I. de Silva from the University of Sheffield proposes that increases in subgenomic RNA (sgRNA) expression cause increased viral transmissibility and subsequent infection. They suggest the ORF9 protein, found in high amounts of sgRNA, could be regulating interferon responses. ....

United Kingdom , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Network Oxford Nanopore , University Of Sheffield , Altered Subgenomic , Oxford Nanopore , Low Quality , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Genomic Sequencing , Health Care , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பல்கலைக்கழகம் ஆஃப் ஷெஃபீல்ட் , குறைந்த தரம் , கொரோனா வைரஸ் , ஆரோக்கியம் பராமரிப்பு , பொது ஆரோக்கியம் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes

Genomic surveillance can help identify how SARS-CoV-2 spreads in care homes
Care homes are at high risk of experiencing outbreaks of COVID-19, the disease caused by SARS-CoV-2. Older people and those affected by heart disease, respiratory disease and type 2 diabetes - all of which increase with age - are at greatest risk of severe disease and even death, making the care home population especially vulnerable.
Care homes are known to be high-risk settings for infectious diseases, owing to a combination of the underlying vulnerability of residents who are often frail and elderly, the shared living environment with multiple communal spaces, and the high number of contacts between residents, staff and visitors in an enclosed space. ....

United Kingdom , Gerry Tonkin Hill , Emily Henderson , University Of Cambridge , Public Health England , Genomics United Kingdom Consortium , Laboratory In Cambridge , Cambridge University Hospitals , Wellcome Sanger Institute , Honorary Consultant , Honorary Senior Visiting Fellow , William Hamilton , Wellcome Sanger , Health Care , Heart Disease , Infection Control , Infectious Diseases , Respiratory Disease , Sars Cov 2 , Type 2 Diabetes , ஒன்றுபட்டது கிஂக்டம் , ஜெர்ரி டான்கின் மலை , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ் , பொது ஆரோக்கியம் இங்கிலாந்து , மரபியல் ஒன்றுபட்டது கிஂக்டம் கூட்டமைப்பு ,

Multiple COVID-19 variants of concern have reached Houston, Texas

Multiple COVID-19 variants of concern have reached Houston, Texas
New research by a team at Houston Methodist Hospital in the United States has modeled the aggressive genomic sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) observed in the United Kingdom to document viral community spread in Houston, Texas.
Houston has thus become the first American city to document four SARS-CoV-2 variants of concern.
Here we report discovery of the UK (B.1.1.7), South Africa (B.1.351), and Brazil (P.1) SARS-CoV-2 variants of concern from patients in the Houston metropolitan region. We also identified geographically-widespread dissemination of the Cal.20C California (B.1.429 and B.1.427) variants of interest. These four SARS-CoV-2 variants are distributed across a large geospatial region in the metropolitan region, indicating successful patient-to-patient transmission among Houstonians.” ....

United States , United Kingdom , South Africa , Los Angeles County , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Centers For Disease , Houston Methodist Hospital , Sequence Analysis , Houston Metropolitan Area Identifies , Widespread Distribution , Multiple Isolates , All Major Variants , Image Credit , Disease Control , Coronavirus Disease Covid 19 , Sars Cov 2 , Amino Acid , Corona Virus , Genomic Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , லாஸ் ஏஞ்சல்ஸ் கவுண்டி , ஜாஸ்லைந் ஸோலிஸ் மோர்ர ,

Evolutionary forces account for gender imbalance in the occurrence of autism, other health conditions

Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded. ....

Rama Singh , Karun Singh , Emily Henderson , University Of Toronto , Shiva Singh , Associate Professor , Cervical Cancer , Mental Health , Ovarian Cancer , ராமா சிங் , கருண் சிங் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , சிவா சிங் , இணை ப்ரொஃபெஸர் , மன இறுக்கம் , சிஇஆர்விஐசிஏஎல் புற்றுநோய் , மன ஆரோக்கியம் , ஓவாயரியந் புற்றுநோய் ,

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19. ....

Lakshmi Supriya , Drug Administration , Phd Mar , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , In Vitro , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் மார் , செல் வரி , கொரோனா வைரஸ் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,