Multiple COVID-19 variants of concern have reached Houston, Texas New research by a team at Houston Methodist Hospital in the United States has modeled the aggressive genomic sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) observed in the United Kingdom to document viral community spread in Houston, Texas. Houston has thus become the first American city to document four SARS-CoV-2 variants of concern. Here we report discovery of the UK (B.1.1.7), South Africa (B.1.351), and Brazil (P.1) SARS-CoV-2 variants of concern from patients in the Houston metropolitan region. We also identified geographically-widespread dissemination of the Cal.20C California (B.1.429 and B.1.427) variants of interest. These four SARS-CoV-2 variants are distributed across a large geospatial region in the metropolitan region, indicating successful patient-to-patient transmission among Houstonians.”