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Study: Heart problems cause disturbed gene activity in the brain's memory center

Study: Heart problems cause disturbed gene activity in the brain s memory center
Heart problems cause disturbed gene activity in the brain s memory center, from which cognitive deficits arise. Researchers at the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center Göttingen (UMG) and the German Center for Cardiovascular Research (DZHK) come to this conclusion based on laboratory studies.
They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. In mice, a specific drug which is known to affect gene activity alleviated the mental deficits. The involved experts see these results as potential approaches for therapies. The study data are published in the scientific journal ....

Emily Henderson , Research Group Leader , Cardiovascular Research , University Medical Center , German Center , Department Of Psychiatry , Neurodegenerative Diseases , Karl Toischer , Alzheimer 39s Disease , Heart Failure , எமிலி ஹென்டர்சன் , ஆராய்ச்சி குழு தலைவர் , இருதய ஆராய்ச்சி , பல்கலைக்கழகம் மருத்துவ மையம் , ஜெர்மன் மையம் , துறை ஆஃப் மனநல மருத்துவம் , இதயம் தோல்வி ,

lockdown: New Zealand's largest city Auckland back to lockdown after COVID-19 case

The patient developed symptoms on Tuesday and is regarded as having been potentially infectious since Sunday, officials said. The person has visited several public venues during that period. ....

New Zealand General , New Zealand , United States , United Kingdom , Jacinda Ardern , Prime Minister Jacinda Ardern , Cup Event , Uk Variant , புதியது ஜீலாந்து ஜநரல் , புதியது ஜீலாந்து , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , கோப்பை நிகழ்வு , இங்கிலாந்து மாறுபாடு ,

World-leading research institutions join forces to find better treatments for pediatric diseases

World-leading research institutions join forces to find better treatments for pediatric diseases
Ahead of Rare Disease Day (28 February), four leading children s research institutions on three continents are joining forces to decipher pediatric illnesses, including rare diseases, and find better treatments.
The four pediatric hospitals Boston Children s Hospital; UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital (London); the Murdoch Children s Research Institute with The Royal Children s Hospital (Melbourne); and The Hospital for Sick Children (SickKids) in Toronto are working together to evaluate genomic data, clinical data from patients, and scientific and medical expertise to accelerate discovery and therapeutic development. ....

United States , City Of , United Kingdom , Emily Henderson , International Precision Child Health Partnership Ipchi , Institute For Child Health , Murdoch Children Research Institute , International Venture Philanthropy Network , Rare Disease Day , Ormond Street Institute , Child Health , Great Ormond Street Hospital , Murdoch Children , Research Institute , Royal Children , Sick Children , International Precision Child Health Partnership , International Venture Philanthropy , Medical Research , Rare Disease , ஒன்றுபட்டது மாநிலங்களில் , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு குழந்தை ஆரோக்கியம் , முர்டோக் குழந்தைகள் ஆராய்ச்சி நிறுவனம் ,

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections
Researchers in Switzerland and Germany have identified host cell factors required for coronavirus replication that could serve as targets for treatment with clinically-approved drugs.
The team found that several autophagy-related genes were common host defense factors required for the replication of both endemic and emerging coronaviruses.
These coronaviruses include the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Autophagy – cellular response to stressors such as hypoxia or infection – involves the recycling of proteins and organelles to maintain homeostasis. Various trafficking pathways enable the transportation of cytoplasmic material to the lysosome, where it is destroyed. ....

Nordrhein Westfalen , Volker Thiel , Meletios Verras Shutterstock , Sally Robertson , Institute Of Virology , Meletios Verras , Middle Eastern , Corona Virus , Coronavirus Disease Covid 19 , Mers Cov , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , வோல்கர் திீஏல் , சாலி ராபர்ட்சன் , நிறுவனம் ஆஃப் வைராலஜி , நடுத்தர கிழக்கு , கொரோனா வைரஸ் , மேற்ச் கோவ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Scientists receive grant to investigate tumor development within a natural environment

Scientists receive grant to investigate tumor development within a natural environment
Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell survival. The relationship between cell and environment also applies to the development of cancer, which a team of Virginia Tech scientists is now researching.
After receiving a $1.4 million grant from the National Institutes of Health (NIH), researchers across multiple disciplines are launching a study to investigate tumor development within a natural environment.
With vital backing by the NIH, the study could provide information key to unraveling the mystery of cancer evolution and, in turn, establishing more effective cancer treatments. ....

United States , Eva Schmelz , Scott Verbridge , Jing Chen , Daniela Cimini , Emily Henderson , Department Of Biological Sciences , College Of Engineering , National Institutes Of Health , Department Of Biomedical Engineering , College Of Science , College Of Agriculture , Department Of Human Nutrition , Fralin Life Sciences Institute , Life Sciences , Virginia Tech , National Institutes , Biological Sciences , Fralin Life Sciences , Biomedical Engineering , Human Nutrition , In Vivo , Research Project , ஒன்றுபட்டது மாநிலங்களில் , ஈவா ஸ்ச்சிமெல்ஜ் , ஜிங் சென் ,