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RNA editing events influence gene expression and phenotypic manifestation


RNA editing events influence gene expression and phenotypic manifestation
Combining computational mining of big data with experimental testing in the lab, researchers at Children s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression.
In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a single nucleotide change by RNA editing can have large downstream effects. The findings were published today in
Genome Biology.
Millions of A-to-I RNA editing sites have been identified across the human transcriptome, but the functions of most RNA editing events are unknown. Understanding how RNA editing affects gene expression and phenotype could help us unravel the genetic basis to many human conditions. ....

United States , Emily Henderson , Study Senior Author , Genomic Medicine , Tissue Expression , Gene Expression , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , படிப்பு மூத்தவர் நூலாசிரியர் , திசு வெளிப்பாடு , கீந் வெளிப்பாடு ,

Interaction between LDL cholesterol and PRS can predict risk of heart attack


Interaction between LDL cholesterol and PRS can predict risk of heart attack
Allelica, a leading genomics software company specializing in developing polygenic risk scores (PRS) for personalized medicine, today announced publication of a study in
Circulation (Vol. 143, Issue 10) showing that the effect of LDL cholesterol on a person s risk of having a heart attack depends on their genes.
Using Allelica s proprietary PRS analysis software, the data showed that combining information on an individual s genetic risk of heart attack with their LDL level helps determine those at most risk from heart attack, including those potentially in need of treatment with statins or PCSK9 inhibitors. ....

Giordano Bott , George Busby , Emily Henderson , Coronary Artery Disease , United Kingdom , Heart Attack , ஜியோர்டானோ பாட்டில் , ஜார்ஜ் பஸ்பி , எமிலி ஹென்டர்சன் , கரோனரி தமனி நோய் , ஒன்றுபட்டது கிஂக்டம் , இதயம் தாக்குதல் ,