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Researchers explain SARS-CoV-2's replication-transcription complex

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still spreading rapidly throughout the world. A new preprint on the bioRxiv server describes the structure of an important viral non-structural protein NSP12-16 and its role in SARS-CoV-2 infection. ....

Liji Thomas , Sars Cov 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Structural Protein , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , கட்டமைப்பு ப்ரோடீந் ,

Direct cloning method aims to accelerate large-scale discovery of novel natural products

Direct cloning method aims to accelerate large-scale discovery of novel natural products
Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.
Now, they have developed a direct cloning method that aims to accelerate large-scale discovery of novel natural products. Their findings are reported in the journal
Nature Communications.
Named Cas12a assisted precise targeted cloning using in vivo Cre-lox recombination (CAPTURE), the method allows for direct cloning of large genomic fragments, including those with high-GC content or sequence repeats. Where existing direct cloning methods fail t ....

Huimin Zhao , Emily Henderson , Stevenl Miller , Nature Communications , Researchers At University Of Illinois Urbana Champaign , Illinois Urbana Champaign , Genomic Biology , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ஆராய்ச்சியாளர்கள் இல் பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் ஊர்பன சாம்பியன் , இல்லினாய்ஸ் ஊர்பன சாம்பியன் ,

Study uncovers how the SARS-CoV-2 B.1.1.7 variant entered the United States

A team led by researchers from the Yale School of Public Health has found how the B.1.1.7 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first found in the United Kingdom, made its way into several states in the United States. ....

United States , New York , New Jersey , United Kingdom , Yale School , Jocelyn Solis Moreirafeb , Nathand Grubaugh , Jocelyn Solis Moreira , Yale School Of Public Health , Public Health , Image Credit , New York Jersey , Saratoga County , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Genomic Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , புதியது ஜெர்சி , ஒன்றுபட்டது கிஂக்டம் , யேல் பள்ளி , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , யேல் பள்ளி ஆஃப் பொது ஆரோக்கியம் ,

Genomic Vision: Financial Information for the Fourth Quarter of 2020

Sales of products and services down 29% to €1.1 million and revenue from activity down 44% to €1.3 million, at end-December 2020 Financial resources offering financial visibility through to ....

United States , Dana Farber Cancer Institute , France General , Dominique Remy Renou , Life Science Research , Research Development , Strategic Communications , Research Tax Credit , Quest Diagnostics , Genomic Vision , Sales Marketing , General Administrative , Thursday April , Thursday May , Meeting Friday June , Thursday July , Thursday October , ஒன்றுபட்டது மாநிலங்களில் , டானா ஃபார்‌பர் புற்றுநோய் நிறுவனம் , பிரான்ஸ் ஜநரல் , வாழ்க்கை அறிவியல் ஆராய்ச்சி , ஆராய்ச்சி வளர்ச்சி , மூலோபாய தகவல்தொடர்புகள் , ஆராய்ச்சி வரி கடன் , தேடலை பரிசோதனை , விற்பனை சந்தைப்படுத்தல் ,

Study outlines the reasons to test pediatric cancer patients for inherited genes

Study outlines the reasons to test pediatric cancer patients for inherited genes
Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there s a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors. Making connections between particular gene mutations and disease requires a lot of data, which until recently has been largely unavailable for pediatric cancers.
Now, tests like MSK-IMPACT
TM can screen tumors for mutations in more than 500 genes as well as analyze patients normal (germline) cells. In the largest study of its kind so far, researchers from Memorial Sloan Kettering s pediatric program, MSK Kids, are reporting germline genomic sequencing details for 751 pediatric patients treated for solid tumors. ....

United States , Elise Fiala , Michael Walsh , Sloan Kettering , Emily Henderson , Kate Niehaus Center , Memorial Sloan Kettering , Nature Cancer , Inherited Cancer , Genomic Sequencing , Lynch Syndrome , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் வால்ஷ் , ஸ்லோன் கெட்டரிங் , எமிலி ஹென்டர்சன் , கேட் னீேோச் மையம் , நினைவகம் ஸ்லோன் கெட்டரிங் , இயற்கை புற்றுநோய் , பரம்பரை புற்றுநோய் , லிஞ்ச் நோய்க்குறி ,