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New SARS-CoV-2 variant emerges in the U.S.

New SARS-CoV-2 variant emerges in the U.S.
Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the
bioRxiv server describes a new American variant that may have become the dominant strain in the USA.
New regional variants arise over the course of a pandemic in part due to lockdowns, which restrict the population movement over a period of time. Another factor is the occurrence of multiple mutations at the same time. Epidemiologic surveillance of an infectious outbreak may involve genomic sequencing, which can allow new variants to be identified early in the course of the disease. ....

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SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

An interesting new preprint research paper that was posted on the bioRxiv server recently describes the use of rigid monoclonal antibodies (mAbs) in contrast to flexible mAbs, and how this affects the binding of multiple mAbs to the same antigen. ....

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New tests may help improve the selection of men considering prostate cancer surveillance

New tests may help improve the selection of men considering prostate cancer surveillance
Sylvester Comprehensive Cancer Center researchers are looking at ways to combine imaging and biomarkers to predict prostate cancer progression more accurately. The study was part of an NCI-funded prospective trial of men who are monitoring their prostate cancer in a management process called active surveillance. Results were recently published in the
Journal of Urology.
Some prostate cancers grow slowly and are unlikely to result in any long-term consequence. As a result, many men with prostate cancer are at risk for overtreatment and related side effects. As a result, active surveillance has emerged as an increasingly popular option for the management of prostate cancer. ....

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Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has marked a new phase in the COVID-19 pandemic. Phylogenetic and epidemiological investigations suggest that the SARS-CoV-2 genetic lineage B.1.1.7 may be associated with increased viral transmissibility among humans. It was also classified as a Variant of Concern (VOC B.1.1.7) in December 2020. First discovered in Kent, United Kingdom, in September 2020, this new variant has since been found in more than 29 countries across the globe, including the USA.
Using phylodynamic methods to study the origins of SARS-CoV-2 B.1.1.7 lineage
In a recent ....

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Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2

Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2
To date, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), has caused more than 93.21 million infections worldwide. As it spreads through different populations, it undergoes adaptations that sometimes affect its transmissibility and other biological characteristics.
An interesting preprint on the
bioRxiv server describes the use of deep learning with image recognition technology to trace the emergence of variants with increased viral fitness. Higher fitness leads to rapid expansion of these lineages in the areas where they are introduced. This type of study could facilitate the development of more effective antibodies and vaccines to help contain the pandemic. ....

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