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Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa | BMC Medicine

West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and asymptomatic cases. Cytokine profiling and antibody quantification were performed using Luminex™ multiplex assay whereas antigen-driven agglutination assay was used to assess the ABO blood groups. Immune profile levels between symptomatic and asymptomatic groups were compared using the two-tailed Mann-Whitney U test. Multiple comparisons of cytokine levels among and between days were tested using Kruskal-Wallis with Dunn’s post hoc test. Correl ....

Cape Coast , United States , San Diego , Tamil Nadu , Greater Accra , Rhodophyta Phycoerythrin , University Of Ghana , Rr Development Core Team , Maxwin Healthcare Pvt Ltd , Graphpad Software , National Research Institute For Sustainable Development , Luminex Corporation , Cape Coast Teaching Hospital , West African Centre , Cell Biology , Infectious Pathogens , Cytokine Human Magnetic , Thermo Fisher Scientific , National Research Institute , Sustainable Development , College Station ,

Mesoporous Silica Nanoparticles Aggravates Atopic Dermatitis

Examining the greater plasma protein adsorption on MSN leads to serious inflammatory reactions in (DFE)-induced mouse atopic dermatitis. Click to read more. ....

United States , Borough Of Bedford , United Kingdom , Baden Wüberg , San Diego , Anton Paar , Laboratory Animals , Cell Lines Service Eppelheim , Micromeritics Instrument Corporation , Public Health Service , Takara Bio Inc , Graphpad Software , Committee Of Kyungpook National University , Carl Zeiss , Orion High Technologies , Micromeritic Tristar , Thermo Fisher Scientific , Lines Service , Silica Nanoparticles , Alexa Fluor , Public Health Service Policy , Humane Care , Institutional Animal Care , Use Committee , Kyungpook National University , Like Skin Inflammation ,

Cureus | Correlation of Breakthrough Infection During the Omicron Wave With Seropositivity of Vaccinated Patients Undergoing Hemodialysis

Background

Patients with chronic kidney disease and undergoing hemodialysis are at greater risk of developing COVID-19. In spite of vaccine efficacy, SARS-CoV-2 breakthrough infection has been reported in several studies. This study was carried out to assess if seroconversion could predict SARS-CoV-2 breakthrough infection in a cohort of vaccinated patients undergoing hemodialysis.

Methodology

Patients undergoing maintenance hemodialysis for at least three months and who had received two doses of BBV152 or AZD1222 vaccine were included in the study. Their baseline IgG antibodies to SARS-CoV-2 were measured and followed up for a median of three months during the third wave of COVID-19 in India with SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) to detect breakthrough infections.

Results

Of 80 patients enrolled, seroconversion was seen in 81% of the cases, and SARS-CoV-2 breakthrough cases have been detected in 16% (13/80 ....

United States , Andhra Pradesh , United Kingdom , New Delhi , San Diego , El Alayli , Kalinga Institute Of Medical Sciences , J Mitra Co , Graphpad Software , Indian Council Of Medical Research , Serum Institute Of India , Thermo Fisher , Serum Institute , Indian Council , Medical Research , Kalinga Institute , Medical Sciences , Institute Ethics Committee , Covid Kawach Igg Microlisa , Kingfisher Duo , Graphpad Prism ,

Depression management and antiretroviral treatment outcome among people living with HIV in Northwest and East regions of Cameroon | BMC Infectious Diseases

Several interventions have shown benefits in improving mental health problems such as depression which is common in people living with HIV. However, there is a paucity of evidence on the effect of these interventions in improving HIV treatment outcomes. This study aimed at bridging this evidence gap and guiding the integration of depression and HIV management, particularly in rural health settings of Cameroon. We carried out a cluster-randomized intervention study targeting persons aged 13 years and above who had been on antiretroviral treatment for 6–9 months. Participants were followed up for 12 months during which those in the intervention group underwent routine screening and management of depression. Comparisons were done using the two-way ANOVA and Chi-squared test with significance set at 5%. Overall, 370 participants with a median age of 39 years (IQR: 30–49) were enrolled in this study. Of these, 42 (11.3%) were screened with mod ....

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Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex

Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex
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Nordrhein Westfalen , Bad Homburg , United States , United Kingdom , San Diego , Bruxelles Capitale , Carl Roth , Merck Millipore , Amersham Biosciences Europe , Partikeltechnologie Gmb , Cytopainter Phalloidin Ifluor , Clontech Takara , University Hospital , Dianova Jackson Immunoresearch Europe Ltd , Odyssey Infrared Imaging System Application Software Version , Graphpad Software , Clinical Research , A Department Of Cell Biology , Ge Healthcare , Department Of Internal Medicine , V Weyer Elberich Institute For Biometrics , University Medical Center , University Medical Center Utrecht , Division Of Molecular Nephrology , Faculty Of The University , Service Facility ,