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WPVI Action News July 8, 2014

Police in buck county search for the gunman in a triple shoot that left one dead. And eating healthy, seniors get help getting fresh fruits and vegetables. But the big story is the big fire that killed four children in southwest philadelphia. Demonstrators were outside of the firehouse around the corner from the deadly blaze, they believe that firefighters took too long to respond. John rawlins, joins us live from the firehouse in southwest philadelphia with more on what is happening today. Reporter hi sara, all is quiet right now, ladder 4 was dispatched six or seven minutes ago. Quite a commotion and confrontation, police can only confirm that one arrest was made and someone charged with disorderly conduct, a man, they are waiting for further numbers. The protest by as many as 200 people was angry and at times chaotic, police at one point dragged protesters trying it leave on an emergency call. The demonstrators claim they were slow to respond to this fire only a block away, two smal ....

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IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAP


Conclusion
In conclusion, we established the healing effects of IGF-1 in chondrocytes and a rabbit model against osteoarthritis. IGF-1 inhibited the NF-κB, p38 (MAPK), and PI3K/AKT signaling pathways, thereby preventing MMPs expression during OA pathogen, and also balanced collagen type II and proteoglycan and formation of hyaline cartilage. Therefore, in articular cartilage lesions, Intra-articular injection of IGF-1 leading a better tactic for effective and efficient therapy. So, our study revealed that IGF-1 could be a potential therapeutic mediator for the management of cartilage damage related to OA. However, our initial finding only on animal and cell levels of anti-OA, further needed to clinical implementation evaluation. ....

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